Mesenchymal stem cells (MSCs) and scaffolds offer promising perspectives for annulus
fibrosus (AF) repair. The repair effect was linked to features of the local mechanical …

Recurrent intervertebral disc (IVD) herniation and degenerative disc disease have been
identified as the most important factors contributing to persistent pain and disability after …

Annulus fibrosus (AF) defect is an important cause of disc re-herniation after discectomy.
The self-regeneration ability of the AF is limited, and AF repair is always hindered by the …

Recurrence of intervertebral disc (IVD) herniation is the most important factor leading to
chronic low back pain and subsequent disability after discectomy. Efficacious annulus …

Objective To explore the repair effect of tissue engineering for annulus fibrosus (AF) injury in
stress-stimulation environment. Methods Non-adhesive fibrinogen (Fib) representing the …

BACKGROUND: Degeneration of the annulus fibrosus (AF), an important structure of the
intervertebral disc, is one of the main causes of degenerative disc disease. Fabrication of …

Due to the deficiency of mechanical supporting after discectomy and weak proliferative
capacity of annulus fibrosus (AF) cells, the AF defect repair remains a clinical challenge …

Background Tissue engineering of the annulus fibrosus (AF) shows promise as a treatment
for patients with degenerative disc disease (DDD). However, it remains challenging due to …

Biomaterial‐based therapy that can restore annulus fibrosus (AF) function in early stage and
promote endogenous repair of AF tissues is a promising approach for AF tissue repair. In …

Repairing damaged annulus fibrosus (AF) is one of the most challenging topics for treating
intervertebral disc (IVD) disease. Tissue engineering combining scaffolds with cells provides …