Objective Several therapies with immune-modulatory functions have been proposed to
reduce the overwhelmed inflammation associated with COVID-19. Here we investigated the …

Interleukin (IL)-10 is a pleiotropic cytokine known for its potent anti-inflammatory and
immunosuppressive effects. Originally identified as a product of T helper 2 cells, IL-10 is now …

Cytokines are major players in orchestrating inflammation, disease pathogenesis, and
severity during COVID-19. Members of the interleukin (IL)-10 family of cytokines play …

Objectives Severe coronavirus disease 2019 (COVID-19) is associated with a dysregulated
immune state. While research has focused on the hyperinflammation, little research has …

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and has been a major threat to global public health. In …

Background The severity of COVID-19 is associated with an elevated level of a variety of
inflammatory mediators. Increasing evidence suggests that the Th17 response contributes to …

The severity of COVID-19 is largely determined by the inflammatory response, a “Cytokine
storm,” that involves both pro-and anti-inflammatory cytokines. In the current study we …

A unique feature of the cytokine storm in coronavirus disease 2019 (COVID-19) is the
dramatic elevation of interleukin 10 (IL-10). This was thought to be a negative feedback …

Background: Deficient interferon responses have been proposed as one of the relevant
mechanisms prompting severe manifestations of COVID-19. Objective: To evaluate the …

Abstract The 2019 coronavirus disease (COVID-19) outbreak caused by the SARS-CoV-2
virus is an ongoing global health emergency. However, the virus' pathogenesis remains …