Objective. Closed-loop experiments provide unique insights into brain dynamics and
function. To facilitate a wide range of closed-loop experiments, we created an open-source …

We present an open-source synchronization software package, PackIO, that can record and
generate voltage signals to enable complex experimental paradigms across multiple …

Highlights•New recording technologies generating massive, complex data sets.•Analysis
workflows are complex, diverse, and fundamentally exploratory.•Rich open-source …

Exponential increases in data volumes and velocities are overwhelming finite human
capabilities. Continued progress in science and engineering demands that we automate a …

The design of modern scientific experiments requires the control and monitoring of many
different data streams. However, the serial execution of programming instructions in a …

Modern neuroscience research often requires the coordination of multiple processes such
as stimulus generation, real-time experimental control, as well as behavioral and neural …

Understanding brain function requires monitoring and interpreting the activity of large
networks of neurons during behavior. Advances in recording technology are greatly …

Closed-loop technologies provide novel ways of online observation, control and
bidirectional interaction with the nervous system, which help to study complex non-linear …

We propose centralized brain observatories for large-scale recordings of neural activity in
mice and non-human primates coupled with cloud-based data analysis and sharing. Such …

In-vivo electrophysiology, the recording of neurons in the brains of awake, behaving
animals, is currently undergoing paradigm shifts. There is a push towards moving to open …