[PDF][PDF] Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition
Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being
developed as therapeutics and are a major contributor to neutralizing antibody responses …
developed as therapeutics and are a major contributor to neutralizing antibody responses …
[HTML][HTML] Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies
Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals
previously infected with SARS-CoV-2, but the relative contributions of these different …
previously infected with SARS-CoV-2, but the relative contributions of these different …
[HTML][HTML] Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies
Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals
previously infected with SARS-CoV-2, but the relative contributions of these different …
previously infected with SARS-CoV-2, but the relative contributions of these different …
[HTML][HTML] Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies
Antibodies elicited in response to infection undergo somatic mutation in germinal centers
that can result in higher affinity for the cognate antigen. To determine the effects of somatic …
that can result in higher affinity for the cognate antigen. To determine the effects of somatic …
[PDF][PDF] Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations
Antibodies elicited by infection accumulate somatic mutations in germinal centers that can
increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related …
increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related …
[PDF][PDF] Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain
Potent neutralizing monoclonal antibodies are one of the few agents currently available to
treat COVID-19. SARS-CoV-2 variants of concern (VOCs) that carry multiple mutations in the …
treat COVID-19. SARS-CoV-2 variants of concern (VOCs) that carry multiple mutations in the …
[PDF][PDF] SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms
Many individuals mount nearly identical antibody responses to SARS-CoV-2. To gain insight
into how the viral spike (S) protein receptor-binding domain (RBD) might evolve in response …
into how the viral spike (S) protein receptor-binding domain (RBD) might evolve in response …
[PDF][PDF] The antigenic anatomy of SARS-CoV-2 receptor binding domain
Antibodies are crucial to immune protection against SARS-CoV-2, with some in emergency
use as therapeutics. Here, we identify 377 human monoclonal antibodies (mAbs) …
use as therapeutics. Here, we identify 377 human monoclonal antibodies (mAbs) …
Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study
Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and
mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
Key substitutions in the spike protein of SARS-CoV-2 variants can predict resistance to monoclonal antibodies, but other substitutions can modify the effects
S Lusvarghi, W Wang, R Herrup… - Journal of …, 2022 - Am Soc Microbiol
Mutations in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants can compromise the effectiveness of therapeutic antibodies. Most clinical …
CoV-2) variants can compromise the effectiveness of therapeutic antibodies. Most clinical …
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