This review concerns the rare, acquired, usually iatrogenic, high-anion-gap metabolic
acidosis, pyroglutamic acidosis. Pyroglutamate is a derivative of the amino acid glutamate …

Long-term use of paracetamol (at therapeutic doses) can cause the accumulation of
endogenous organic pyroglutamate, resulting in metabolic acidosis with an elevated anion …

Pyroglutamic acidemia is an uncommon metabolic disorder, which is usually diagnosed at
early ages. The mechanism of action is thought to be glutathione depletion, and its clinical …

An 84-year-old woman presented in extremis with confusion and Kussmaul respiration. She
had a history of urosepsis, renal impairment and osteoarthrosis. The venous blood gas …

Metabolic acidosis is a common clinical disturbance due to increased plasma acidity caused
by a primary decrease in serum HCO3-concentration. It is classified as normal or high anion …

A 50-year-old man was transferred to the intensive care unit with high anion gap metabolic
acidosis. Investigations suggested a diagnosis of pyroglutamic acidaemia. Factors …

Pyroglutamic aciduria (McKusick 26613) is associated with deficiencies of glutathione
synthetase (EC 6.3. 2.3)(Wellner et al., 1974) or 5-oxoprolinase (EC 3.5. 2.9)(Larsson et at …

Pyroglutamic acid is an endogenous organic acid and a metabolite in the γ-glutamyl cycle,
involved in glutathione metabolism. Accumulation of pyroglutamic acid is a rare cause of …

A case study is presented of a 73-year-old man who developed high anion gap metabolic
acidosis (HAGMA) in a sub-acute care setting from prolonged acetaminophen and …

Pyroglutamic acidemia, a rare metabolic disorder, usually appears in infancy. It is
characterized by retardation, ataxia, hemolytic anemia, and chronic acidosis and is caused …