Novel therapeutic targets for inflammatory bowel disease

M Argollo, G Fiorino, P Hindryckx, L Peyrin-Biroulet… - Journal of …, 2017 - Elsevier
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and Ulcerative Colitis
(UC), are immune mediated conditions associated with progressive damage of the inflamed …

[HTML][HTML] Inflammatory bowel disease: updates on molecular targets for biologics

KH Katsanos, KA Papadakis - Gut and Liver, 2017 - ncbi.nlm.nih.gov
Therapy for inflammatory bowel disease (IBD) has changed, with several new agents being
evaluated. The era of anti-tumor necrosis factor (anti-TNF) antibody therapy saw remarkable …

Novel targeted therapies for inflammatory bowel disease

M Coskun, S Vermeire, OH Nielsen - Trends in pharmacological sciences, 2017 - cell.com
Our growing understanding of the immunopathogenesis of inflammatory bowel disease
(IBD) has opened new avenues for developing targeted therapies. These advances in …

New and emerging treatments for inflammatory bowel disease

M Higashiyama, R Hokari - Digestion, 2023 - karger.com
Background: The specific etiopathogenesis of inflammatory bowel disease (IBD) is still
unknown. Although the conventional anti-inflammatory or immunomodulatory drugs …

Gut inflammation: current update on pathophysiology, molecular mechanism and pharmacological treatment modalities

K Gyires, E Viktoria Toth… - Current pharmaceutical …, 2014 - ingentaconnect.com
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory condition of the
gastrointestinal tract. The two main forms of IBD are Crohn's disease and ulcerative colitis …

Novel pharmacological approaches for inflammatory bowel disease: Targeting key intracellular pathways and the IL‐23/IL‐17 axis

LR Fitzpatrick - International Journal of Inflammation, 2012 - Wiley Online Library
This review identifies possible pharmacological targets for inflammatory bowel disease (IBD)
within the IL‐23/IL‐17 axis. Specifically, there are several targets within the IL‐23/IL‐17 …

Mechanism-based treatment strategies for IBD: cytokines, cell adhesion molecules, JAK inhibitors, gut flora, and more

P Schreiner, MF Neurath, SC Ng, EM El-Omar… - Inflammatory intestinal …, 2019 - karger.com
Background: Although TNF inhibitors revolutionized the therapy of inflammatory bowel
disease (IBD), we have been reaching a point where other therapies with different …

[HTML][HTML] Inflammatory pathways of importance for management of inflammatory bowel disease

J Pedersen, M Coskun, C Soendergaard… - World journal of …, 2014 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) is a group of chronic disorders of the gastrointestinal tract
comprising Crohn's disease (CD) and ulcerative colitis (UC). Their etiologies are unknown …

Inflammatory bowel disease: etiology, pathogenesis and current therapy

JK Ko, KK Auyeung - Current pharmaceutical design, 2014 - ingentaconnect.com
Ulcerative colitis (UC) and Crohn's disease (CD) constitute the two major groups of
idiopathic disorders in inflammatory bowel disease (IBD). Environmental factors, genetic …

[HTML][HTML] Inflammatory bowel disease: emerging therapies and future treatment strategies

E Bretto, DG Ribaldone, GP Caviglia, GM Saracco… - Biomedicines, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a term used to represent a group of chronic, relapsing
inflammatory disorders of the gastrointestinal tract. Crohn's disease (CD) and ulcerative …