Evolving complexity of MIF signaling

SS Jankauskas, DWL Wong, R Bucala, S Djudjaj… - Cellular signalling, 2019 - Elsevier
Macrophage migration inhibitory factor (MIF) is a cytokine expressed in various cell types,
including hematopoietic, epithelial, endothelial, mesenchymal and neuronal cells. Altered …

Macrophage migration inhibitory factor (MIF): a multifaceted cytokine regulated by genetic and physiological strategies

K Sumaiya, D Langford, K Natarajaseenivasan… - Pharmacology & …, 2022 - Elsevier
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine encoded within a
functionally polymorphic genetic locus. MIF was initially recognized as a cytokine generated …

[HTML][HTML] Insight into the biology of macrophage migration inhibitory factor (MIF) revealed by the cloning of its cell surface receptor

L Leng, R Bucala - Cell Research, 2006 - nature.com
The recent cloning of MIF receptor fills an important gap in our understanding of the
molecular biology and immunology of MIF. The MIF receptor, like MIF, does not fall into any …

[HTML][HTML] Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury

S Song, Z Xiao, FJ Dekker, GJ Poelarends… - Cellular and Molecular …, 2022 - Springer
The family of macrophage migration inhibitory factor (MIF) proteins in humans consist of MIF,
its functional homolog D-dopachrome tautomerase (D-DT, also known as MIF-2) and the …

[HTML][HTML] Macrophage migration inhibitory factor (MIF): a promising biomarker

G Grieb, M Merk, J Bernhagen… - Drug news & …, 2010 - ncbi.nlm.nih.gov
Macrophage migration inhibitory (MIF) factor is an immunoregulatory cytokine whose effect
on arresting random immune cell movement was recognized several decades ago. Despite …

MIF, a controversial cytokine: a review of structural features, challenges, and opportunities for drug development

J Bloom, S Sun, Y Al-Abed - Expert opinion on therapeutic targets, 2016 - Taylor & Francis
Introduction: Macrophage migration inhibitory factor (MIF) has emerged as a promising drug
target in diseases including sepsis, rheumatoid arthritis, and cancer. MIF has multiple …

MIF signal transduction initiated by binding to CD74

L Leng, CN Metz, Y Fang, J Xu, S Donnelly… - The Journal of …, 2003 - rupress.org
Macrophage migration inhibitory factor (MIF) accounts for one of the first cytokine activities to
have been described, and it has emerged recently to be an important regulator of innate and …

[HTML][HTML] Macrophage migration inhibitory factor (MIF): mechanisms of action and role in disease

H Lue, R Kleemann, T Calandra, T Roger… - Microbes and …, 2002 - Elsevier
Macrophage migration inhibitory factor (MIF) is a unique cytokine and critical mediator of
host defenses with a role in septic shock and chronic inflammatory and autoimmune …

Macrophage migration inhibitory factor: a therapeutic target across inflammatory diseases

AY Hoi, MN Iskander, EF Morand - Inflammation & Allergy-Drug …, 2007 - ingentaconnect.com
Macrophage migration inhibitory factor (MIF), a cytokine originally reported in the 1960s as
the prototypic T lymphokine, has emerged in recent years as a key factor regulating …

The vascular biology of macrophage migration inhibitory factor (MIF)

Y Asare, M Schmitt, J Bernhagen - Thrombosis and …, 2013 - thieme-connect.com
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with chemokine-like
functions. MIF is a critical mediator of the host immune and inflammatory response …