CYR61 (CCN1) is essential for placental development and vascular integrity

FE Mo, AG Muntean, CC Chen, DB Stolz… - … and cellular biology, 2002 - Taylor & Francis
CYR61 (CCN1) is a member of the CCN family of secreted matricellular proteins that
includes connective tissue growth factor (CCN2), NOV (CCN3), WISP-1 (CCN4), WISP-2 …

[HTML][HTML] Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins αvβ3 and α6β1 in human umbilical vein endothelial cells

SJ Leu, SCT Lam, LF Lau - Journal of Biological Chemistry, 2002 - ASBMB
CYR61 (CCN1) is an extracellular matrix-associated protein of the CCN family, which also
includes CTGF (CCN2), NOV (CCN3), WISP-1 (CCN4), WISP-2 (CCN5), and WISP-3 …

Functional properties and intracellular signaling of CCN1/Cyr61

Y Chen, XY Du - Journal of cellular biochemistry, 2007 - Wiley Online Library
CCN1/Cyr61 is a member of the protein family that can be promptly induced by growth
factors. CCN1/Cyr61 promotes cell proliferation, adhesion, and differentiation. It plays …

Decreased expression of the angiogenic regulators CYR61 (CCN1) and NOV (CCN3) in human placenta is associatedwith pre-eclampsia

A Gellhaus, M Schmidt, C Dunk, SJ Lye… - MHR: Basic science …, 2006 - academic.oup.com
The pregnancy disorder pre-eclampsia (PE) is thought to be caused in part by shallow
invasion of the extravillous trophoblast (EVT) leading to uteroplacental insufficiency and …

CCN1/CYR61: the very model of a modern matricellular protein

LF Lau - Cellular and Molecular Life Sciences, 2011 - Springer
Abstract CCN1 (CYR61) is a dynamically expressed, multifunctional matricellular protein
that plays essential roles in cardiovascular development during embryogenesis, and …

[HTML][HTML] The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts

CC Chen, FE Mo, LF Lau - Journal of Biological Chemistry, 2001 - ASBMB
Cyr61 is a heparin-binding, extracellular matrix-associated protein of the CCN family, which
also includes connective tissue growth factor, Nov, WISP-1, WISP-2, and WISP-3. Cyr61 is …

[HTML][HTML] Identification of a novel integrin αvβ3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells

N Chen, SJ Leu, V Todorovic, SCT Lam… - Journal of Biological …, 2004 - ASBMB
CCN1 (CYR61) is a matricellular inducer of angiogenesis essential for successful vascular
development. Though devoid of the canonical RGD sequence motif recognized by some …

[HTML][HTML] CYR61 stimulates human skin fibroblast migration through integrin αvβ5 and enhances mitogenesis through integrin αvβ3, independent of its carboxyl …

TM Grzeszkiewicz, DJ Kirschling, N Chen… - Journal of Biological …, 2001 - ASBMB
CYR61, an angiogenic factor and a member of the CCN protein family, is an extracellular
matrix-associated, heparin-binding protein that mediates cell adhesion, promotes cell …

[HTML][HTML] Cyr61 suppresses growth of human endometrial cancer cells

W Chien, T Kumagai, CW Miller, JC Desmond… - Journal of Biological …, 2004 - ASBMB
Cyr61 (CCN1) is a member of the CCN protein family; these secreted proteins are involved
in diverse biological processes such as cell adhesion, angiogenesis, apoptosis, and either …

Human CYR61-mediated enhancement of bFGF-induced DNA synthesis in human umbilical vein endothelial cells

TV Kolesnikova, LF Lau - Oncogene, 1998 - nature.com
CYR61 is a member of an emerging family of growth regulators that includes the human
connective tissue growth factor and the chicken protooncoprotein Nov. Encoded by a growth …