Magnetic and pH-Responsive Magnetite/Chitosan (Core/Shell) Nanoparticles for Dual-Targeted Methotrexate Delivery in Cancer Therapy

A Medina-Moreno, MM El-Hammadi, GI Martínez-Soler… - 2024 - researchsquare.com
Methotrexate successful therapy encounters various challenges in chemotherapy, such as
poor oral bioavailability, low specificity, side effects and the development of drug …

[HTML][HTML] Multifunctional antitumor magnetite/chitosan-l-glutamic acid (core/shell) nanocomposites

DP Santos, MA Ruiz, V Gallardo, MVB Zanoni… - Journal of Nanoparticle …, 2011 - Springer
The development of anticancer drug delivery systems based on biodegradable
nanoparticles has been intended to maximize the localization of chemotherapy agents …

Pegylated and amphiphilic Chitosan coated manganese ferrite nanoparticles for pH-sensitive delivery of methotrexate: Synthesis and characterization

Z Karimi, S Abbasi, H Shokrollahi, G Yousefi… - Materials Science and …, 2017 - Elsevier
Magnetic nanoparticles (MNPs) are the major class of nanoparticles (NPs) with specific
functional properties that make them good candidates for biomedical applications. Due to …

Triple-responsive drug nanocarrier: Magnetic core-shell nanoparticles of Fe3O4@ poly (N-isopropylacrylamide)-grafted-chitosan, synthesis and in vitro cytotoxicity …

S Moradi, R Najjar, H Hamishehkar, A Lotfi - Journal of Drug Delivery …, 2022 - Elsevier
Herein, synthesis, characterization and cytotoxicity evaluation of core-shell nanoparticles of
magnetic Fe 3 O 4-poly (N-isopropylacrylamide)(PNIPAAm) grafted with chitosan, as …

PEG-chitosan-coated iron oxide nanoparticles with high saturated magnetization as carriers of 10-hydroxycamptothecin: preparation, characterization and cytotoxicity …

JB Qu, HH Shao, GL Jing, F Huang - Colloids and surfaces B: Biointerfaces, 2013 - Elsevier
A magnetic nano-sized carrier for 10-hydroxycamptothecin (HCPT) was prepared by using
Fe3O4 nanoparticles as cores and chitosan (CS) as a polymeric shell by a novel reverse …

Glucosamine-modified mesoporous silica-coated magnetic nanoparticles: a “Raisin-Cake”-like structure as an efficient theranostic platform for targeted methotrexate …

F Farjadian, Z Faghih, M Fakhimi, P Iranpour… - Pharmaceutics, 2023 - mdpi.com
This study presents the synthesis of glucosamine-modified mesoporous silica-coated
magnetic nanoparticles (MNPs) as a therapeutic platform for the delivery of an anticancer …

Chitosan-coated magnetic nanorods and nanospheres: physicochemical characterizations and potential as methotrexate carriers for targeted drug delivery

SM Taghizadeh, N Lal… - Zeitschrift für …, 2024 - degruyter.com
Spherical magnetite nanoparticles were employed in the almost all magnetic based drug
delivery studies. But as we all know the shape of employed particles is one of the major …

Evaluation of supramolecule conjugated magnetic nanoparticles as a simultaneous carrier for methotrexate and tamoxifen

A Sargazi, M Azhoogh, S Allahdad, MH Majd - Journal of Drug Delivery …, 2018 - Elsevier
Supramolecular host–guest complexes have the ability to prolong the circulation time, and
promote the efficiency of hydrophobic drugs. Therefore, in this project we immobilized …

Biocompatible magnetic tris (2-aminoethyl) amine functionalized nanocrystalline cellulose as a novel nanocarrier for anticancer drug delivery of methotrexate

M Rahimi, S Shojaei, KD Safa, Z Ghasemi… - New Journal of …, 2017 - pubs.rsc.org
In cancer therapy, biocompatible and smart nanocarriers are the most important types of
therapeutic agents. In this paper, a novel magnetic nanocarrier was fabricated and …

Targeted delivery of methotrexate using a new PEGylated magnetic/gold nanoplatform covered with pH‐responsive shell

M Ghorbani, M Zarei, F Mahmoodzadeh… - International Journal of …, 2021 - Taylor & Francis
Because of nonspecific biodistribution, and the resistance of cancer cells to
chemotherapeutic agents, it is possible to develop cancer nanotherapeutics that are being …