Simple Summary Despite the advancements in systemic treatments, the incidence of brain
metastasis (BM) is increasing. BM is a multi-step cascade. One critical event in BM is the …

Our understanding of the process of metastatic progression has improved markedly over the
past decades, yet metastasis remains the most enigmatic component of cancer …

The majority of brain metastases originate from lung cancer, breast cancer and malignant
melanoma. In order to reach the brain, parenchyma metastatic cells have to transmigrate …

Although brain metastases are common in cancer patients, little is known about the
mechanisms of cancer extravasation across the blood-brain barrier (BBB), a key step in the …

Brain metastasis is an important cause of mortality in patients with cancer and represents the
majority of all intracranial tumors. A key step during the metastatic journey of the cancer cell …

Metastasis to the central nervous system (CNS) remains a major cause of morbidity and
mortality in patients with systemic cancer. As the length of survival in patients with systemic …

Brain metastases outnumber the incidence of brain tumors by a factor of ten. Patients with
brain metastases have a dismal prognosis and current treatment modalities achieve only a …

Despite improvements in extracranial therapy, survival rate for patients suffering from brain
metastases remains very poor. This is coupled with the incidence of brain metastases …

Simple Summary Brain metastases are the most common brain tumor in adults and are
associated with poor prognosis. The propensity of different solid tumors to metastasize …

Cancer metastases into the brain constitute one of the most severe, but not uncommon,
manifestations of cancer progression. Several factors control how cancer cells interact with …