Fitness of cells is dependent on protein homeostasis which is maintained by cooperative
activities of protein chaperones and proteolytic machinery. Upon encountering protein …

Heat shock factor 1 (HSF1) is the primary component for initiation of the powerful heat shock
response (HSR) in eukaryotes. The HSR is an evolutionarily conserved mechanism for …

The heat-shock, or HSF1-mediated proteotoxic stress, response (HSR/HPSR) is
characterized by induction of heat-shock proteins (HSPs). As molecular chaperones, HSPs …

Heat shock proteins (HSP) are a subset of the molecular chaperones, best known for their
rapid and abundant induction by stress. HSP genes are activated at the transcriptional level …

Abstract Heat shock factor 1 (HSF1) systematically guards proteome stability and
proteostasis by regulating the expression of heat shock protein (HSP), thus rendering cancer …

The ability of cancer cells to cope with stressful conditions is critical for their survival,
proliferation, and metastasis. The heat shock transcription factor 1 (HSF1) protects cells from …

Malignant transformation is accompanied by alterations in the key cellular pathways that
regulate development, metabolism, proliferation and motility as well as stress resilience. The …

In their role as molecular chaperones, heat shock proteins serve as central integrators of
protein homeostasis within cells. As part of this function, they guide the folding, assembly …

Summary Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response,
facilitates malignant transformation, cancer cell survival, and proliferation in model systems …

Heat shock factor 1 (HSF1) was discovered in 1984 as the master regulator of the heat
shock response. In this classical role, HSF1 is activated following cellular stresses such as …