Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside

YY Ma, X Li, JT Yu, YJ Wang - Translational Neurodegeneration, 2024 - Springer
The aetiologies and origins of neurodegenerative diseases, such as Alzheimer's disease
(AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's …

The dichotomous role of the gut microbiome in exacerbating and ameliorating neurodegenerative disorders

U Raval, JM Harary, E Zeng… - Expert review of …, 2020 - Taylor & Francis
Introduction Age related neurodegenerative disorders affect millions of people around the
world. The role of the gut microbiome (GM) in neurodegenerative disorders has been …

The gut microbiome: an important role in neurodegenerative diseases and their therapeutic advances

S Li, L Zhao, J Xiao, Y Guo, R Fu, Y Zhang… - Molecular and cellular …, 2023 - Springer
There are complex interactions between the gut and the brain. With increasing research on
the relationship between gut microbiota and brain function, accumulated clinical and …

The role of the gut microbiota in neurodegenerative diseases

A Philip Mani, B Balasubramanian, LA Mali… - Microbiology …, 2024 - mdpi.com
The human gut has a rich and dynamic microbial population that plays an important role in
many physiological activities. This review explores the complex interaction between the gut …

Gut microbiota regulation and their implication in the development of neurodegenerative disease

P Sun, L Su, H Zhu, X Li, Y Guo, X Du, L Zhang, C Qin - Microorganisms, 2021 - mdpi.com
In recent years, human gut microbiota have become one of the most promising areas of
microorganism research; meanwhile, the inter-relation between the gut microbiota and …

Influence of the gut microbiota on the development of neurodegenerative diseases

MP Singh, R Chakrabarty, S Shabir… - Mediators of …, 2022 - Wiley Online Library
Neurodegenerative disorders are marked by neuronal death over time, causing a variety of
cognitive and motor dysfunctions. Protein misfolding, neuroinflammation, and mitochondrial …

Modification of the gut microbiome to combat neurodegeneration

AO Sasmita - Reviews in the Neurosciences, 2019 - degruyter.com
The gut microbiome was extensively researched for its biological variety and its potential
role in propagating diseases outside of the gastrointestinal (GI) tract. Recently, a lot of effort …

Implications of gut microbiota in neurodegenerative diseases

H Zhang, Y Chen, Z Wang, G Xie, M Liu… - Frontiers in …, 2022 - frontiersin.org
The morbidity associated with neurodegenerative diseases (NDs) is increasing, posing a
threat to the mental and physical quality of life of humans. The crucial effect of microbiota on …

Gut microbiota as a hidden player in the pathogenesis of Alzheimer's disease

H Choi, D Lee, I Mook-Jung - Journal of Alzheimer's Disease, 2022 - content.iospress.com
Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
accompanied by cognitive impairment and shows representative pathological features …

Gastrointestinal dysfunction in neurological and neurodegenerative disorders

J Raber, TJ Sharpton - Seminars in neurology, 2023 - thieme-connect.com
Increasing research links the gut microbiome to neurodegenerative disorders. The gut
microbiome communicates with the central nervous system via the gut–brain axis and affects …