Objective Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a key role in the
pathogenesis of osteoarthritis (OA). Growth factors (GFs) capable of antagonizing the …

Purpose The pathogenesis of osteoarthritis (OA) is characterized by joint degeneration. The
pro-inflammatory cytokine interleukin (IL)-1β plays a vital role in the pathogenesis of OA by …

Objective Transforming growth factor-β (TGF-β) is an important homeostatic regulator of
cartilage. In contrast, interleukin-6 (IL-6) is a pro-inflammatory cytokine implicated in …

In osteoarthritis (OA), interleukin-1 (IL-1) stimulates the expression of metalloproteinases
and aggrecanases, which induce cartilage degradation. IL-1 is also capable of reducing the …

Objective. In OA, there is enhanced expression of pro-inflammatory cytokines such as IL-1β
in the affected joint. Delphinidin, an anthocyanidin found in pigmented fruits and vegetables …

Activation of NF-κB signaling promotes osteoarthritis (OA) through the transcriptional
induction of Hif-2α and catabolic enzymes. This study sought to examine whether inhibiting …

Summary Objective Interleukin-1 (IL-1) is an alleged important cytokine in osteoarthritis
(OA), although the exact contribution of IL-1 to joint destruction remains unclear. Here we …

Interleukin (IL)-1β is a major catabolic pro-inflammatory cytokine involved in cartilage
destruction-associated processes, such as loss of the differentiated chondrocyte phenotype …

OBJECTIVE: To elucidate the antagonism between interleukin-1 (IL-1) and transforming
growth factor-β (TGF-β) at the gene expression level, as IL-1 and TGF-β are postulated to be …

Interleukin-1ß is a pro-inflammatory cytokine that causes anti-anabolic and catabolic effects
on articular chondrocytes via four major signaling pathways. In this study, we investigated …