Tantalum–Zirconium Co‐Doped Metal–Organic Frameworks Sequentially Sensitize Radio–Radiodynamic–Immunotherapy for Metastatic Osteosarcoma

T Li, M Gao, Z Wu, J Yang, B Mo, S Yu… - Advanced …, 2023 - Wiley Online Library
Due to radiation resistance and the immunosuppressive microenvironment of metastatic
osteosarcoma, novel radiosensitizers that can sensitize radiotherapy (RT) and antitumor …

Nanoscale metal-organic frameworks for x-ray activated in situ cancer vaccination

K Ni, G Lan, N Guo, A Culbert, T Luo, T Wu… - Science …, 2020 - science.org
Cancer vaccines have been actively pursued to bolster antitumor immunity. Here, we
designed nanoscale metal-organic frameworks (nMOFs) as locally activable …

Monte Carlo Simulation‐Guided Design of a Thorium‐Based Metal–Organic Framework for Efficient Radiotherapy‐Radiodynamic Therapy

Z Xu, T Luo, J Mao, C McCleary… - Angewandte Chemie …, 2022 - Wiley Online Library
High‐Z metal‐based nanoscale metal–organic frameworks (nMOFs) with photosensitizing
ligands can enhance radiation damage to tumors via a unique radiotherapy‐radiodynamic …

Nanoscale Metal–Organic Framework with an X-ray Triggerable Prodrug for Synergistic Radiotherapy and Chemotherapy

Z Xu, W Zhen, C McCleary, T Luo, X Jiang… - Journal of the …, 2023 - ACS Publications
As heavy-metal-based nanoscale metal–organic frameworks (nMOFs) are excellent
radiosensitizers for radiotherapy via enhanced energy deposition and reactive oxygen …

Interfering biosynthesis by nanoscale metal-organic frameworks for enhanced radiation therapy

Z Fu, Z Liu, J Wang, L Deng, H Wang, W Tang, D Ni - Biomaterials, 2023 - Elsevier
Radiation therapy (RT) is one of the most widely used cancer treatments. However, the
vigorous biosynthesis of cancer cells plays an important role for RT resistance. Herein, we …

Designing Bimetallic Metal‐Organic Framework‐Based Heterojunction Radiosensitizer for Enhanced Radiodynamic Therapy and Immunotherapy

Z Xiong, M Yang, P Liu, Z Tang, Y Yang… - Advanced Functional …, 2024 - Wiley Online Library
Radiotherapy, as one of the most common strategies for clinical cancer treatment, suffers
from failure due to the hypoxia, inflammation, and radiosensitivity difference of malignant …

2D Copper (II) Metalated Metal–Organic Framework Nanocomplexes for Dual-enhanced Photodynamic Therapy and Amplified Antitumor Immunity

Z Chen, Y Wu, Z Yao, J Su, Z Wang… - ACS Applied Materials …, 2022 - ACS Publications
The immunosuppressive tumor microenvironment (TME) poses tremendous challenges for
efficient immunotherapy. Smart nanomedicine is designed to modulate immunosuppressive …

Metal–organic framework-based nanoagents for effective tumor therapy by dual dynamics-amplified oxidative stress

J Chen, Y Wang, H Niu, Y Wang, A Wu… - … Applied Materials & …, 2021 - ACS Publications
Overproduction of reactive oxygen species (ROS) within tumors can cause oxidative stress
on tumor cells to induce death, which has motivated us to develop ROS-mediated tumor …

Polydopamine-cloaked Fe-based metal organic frameworks enable synergistic multidimensional treatment of osteosarcoma

Y Wang, GR Williams, Y Zheng, H Guo, S Chen… - Journal of Colloid and …, 2023 - Elsevier
One of the major challenges in effective cancer therapy arises because of the hypoxic
microenvironment in the tumor. This compromises the efficacy of both chemo-and …

High‐Z Metal–Organic Frameworks for X‐ray Radiation‐Based Cancer Theranostics

MJ Neufeld, A Lutzke, G Pratx… - Chemistry–A European …, 2021 - Wiley Online Library
X‐ray radiation is commonly employed in clinical practice for diagnostic and therapeutic
applications. Over the past decade, developments in nanotechnology have led to the use of …