An extracellular vesicle targeting ligand that binds to Arc proteins and facilitates Arc transport in vivo
PH Lee, M Anaya, MS Ladinsky, JM Reitsma, K Zinn - Elife, 2023 - elifesciences.org
Communication between distant cells can be mediated by extracellular vesicles (EVs) that
deliver proteins and RNAs to recipient cells. Little is known about how EVs are targeted to …
deliver proteins and RNAs to recipient cells. Little is known about how EVs are targeted to …
Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag
MA Cottee, SC Letham, GR Young, JP Stoye… - Science advances, 2020 - science.org
The tetrapod neuronal protein ARC and its Drosophila melanogaster homolog, dARC1,
have important but differing roles in neuronal development. Both are thought to originate …
have important but differing roles in neuronal development. Both are thought to originate …
Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins
S Erlendsson, DR Morado, HB Cullen… - Nature …, 2020 - nature.com
Arc, a neuronal gene that is critical for synaptic plasticity, originated through the
domestication of retrotransposon Gag genes and mediates intercellular messenger RNA …
domestication of retrotransposon Gag genes and mediates intercellular messenger RNA …
Phosphatidylinositol 3-phosphate mediates Arc capsids secretion through the multivesicular body pathway
K Mehta, H Yentsch, J Lee, TT Gao, K Zhang - bioRxiv, 2023 - biorxiv.org
Activity-regulated cytoskeleton-associated protein (Arc/Arg3. 1) is an immediate early gene
that plays a vital role in learning and memory. The recent discovery that Arc mediates the …
that plays a vital role in learning and memory. The recent discovery that Arc mediates the …
[HTML][HTML] Retrovirus-like Gag protein Arc1 binds RNA and traffics across synaptic boutons
J Ashley, B Cordy, D Lucia, LG Fradkin, V Budnik… - Cell, 2018 - cell.com
Summary Arc/Arg3. 1 is required for synaptic plasticity and cognition, and mutations in this
gene are linked to autism and schizophrenia. Arc bears a domain resembling retroviral …
gene are linked to autism and schizophrenia. Arc bears a domain resembling retroviral …
Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc
EI Hallin, S Markússon, L Böttger, AE Torda… - PloS one, 2021 - journals.plos.org
Synaptic plasticity is vital for brain function and memory formation. One of the key proteins in
long-term synaptic plasticity and memory is the activity-regulated cytoskeleton-associated …
long-term synaptic plasticity and memory is the activity-regulated cytoskeleton-associated …
[HTML][HTML] The neuronal gene arc encodes a repurposed retrotransposon gag protein that mediates intercellular RNA transfer
ED Pastuzyn, CE Day, RB Kearns, M Kyrke-Smith… - Cell, 2018 - cell.com
The neuronal gene Arc is essential for long-lasting information storage in the mammalian
brain, mediates various forms of synaptic plasticity, and has been implicated in …
brain, mediates various forms of synaptic plasticity, and has been implicated in …
Development and validation of Arc nanobodies: new tools for probing Arc dynamics and function
Y Ishizuka, TF Mergiya, R Baldinotti, J Xu… - Neurochemical …, 2022 - Springer
Activity-regulated cytoskeleton-associated (Arc) protein plays key roles in long-term synaptic
plasticity, memory, and cognitive flexibility. However, an integral understanding of Arc …
plasticity, memory, and cognitive flexibility. However, an integral understanding of Arc …
Structure of D. melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag
MA Cottee, SC Letham, GR Young, JP Stoye, IA Taylor - bioRxiv, 2019 - biorxiv.org
The tetrapod neuronal protein ARC and its D. melanogaster homologue, dARC1, have
important but differing roles in neuronal development. Both are thought to originate through …
important but differing roles in neuronal development. Both are thought to originate through …
Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling
M Avallone, J Pardo, TF Mergiya, J Rájová… - Frontiers in Molecular …, 2023 - frontiersin.org
The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity
and memory formation. The Arc gene, which contains remnants of a structural GAG …
and memory formation. The Arc gene, which contains remnants of a structural GAG …