Chronic kidney disease (CKD) is characterized by the loss of kidney function. The molecular
mechanisms underlying the development and progression of CKD are still not fully …

The aim of this study was to establish a peptidomic profile based on LC-MS/MS and random
forest (RF) algorithm to distinguish the urinary peptidomic scenario of type 2 diabetes …

Mechanisms underlying the onset and progression of nephropathy in diabetic patients are
not fully elucidated. Deregulation of proteolytic systems is a known path leading to disease …

Urinary peptidomics focuses on endogenous urinary peptide content. Many studies now
show the usefulness of this approach for the discovery and validation of biomarkers in …

Given the pathophysiological continuum of chronic kidney disease (CKD), different
molecular determinants affecting progression may be associated with distinct disease …

Introduction The identification of patients with chronic kidney disease (CKD) at risk of
progressing to kidney failure (KF) is important for clinical decision-making. In this study we …

Native biofluid peptides offer important information about diseases, holding promise as
biomarkers. Particularly, the non-invasive nature of urine sampling, and its high peptide …

Biomarker development, improvement, and clinical implementation in the context of kidney
disease have been a central focus of biomedical research for decades. To this point, only …

Chronic kidney disease (CKD) may progress to end-stage renal disease (ESRD) at different
pace. Early markers of disease progression could facilitate and improve patient …

In order to effectively develop personalized medicine for kidney diseases we urgently need
to develop highly accurate biomarkers for use in the clinic, since current biomarkers of …