Polymorphisms at LDLR locus may be associated with coronary artery disease through modulation of coagulation factor VIII activity and independently from lipid …
N Martinelli, D Girelli, B Lunghi, M Pinotti… - Blood, The Journal …, 2010 - ashpublications.org
High levels of coagulation factor VIII (FVIII) have been associated with cardiovascular
disease. Low-density lipoprotein receptor (LDLR) has been recently demonstrated to …
disease. Low-density lipoprotein receptor (LDLR) has been recently demonstrated to …
Low-density lipoprotein receptor-related protein polymorphisms in patients with elevated factor VIII coagulant activity and venous thrombosis
N Cunningham, MA Laffan, RA Manning… - Blood coagulation & …, 2005 - journals.lww.com
Elevated factor VIII coagulant activity (FVIII: C) levels (> 150 IU/dl) represent a prevalent
independent risk factor for venous thromboembolism (VTE). Low-density lipoprotein receptor …
independent risk factor for venous thromboembolism (VTE). Low-density lipoprotein receptor …
[HTML][HTML] Low‐density lipoprotein receptor‐related protein 1 polymorphism 663 C> T affects clotting factor VIII activity and increases the risk of venous …
R Vormittag, P Bencur, C Ay, T Tengler… - Journal of Thrombosis …, 2007 - Elsevier
Background: Clotting factor (F) VIII is an independent risk factor for primary and recurrent
venous thromboembolism (VTE). The causes for high plasma FVIII levels are not fully …
venous thromboembolism (VTE). The causes for high plasma FVIII levels are not fully …
Coagulation factors and the risk of ischemic heart disease: a Mendelian randomization study
JV Zhao, CM Schooling - Circulation: Genomic and Precision …, 2018 - Am Heart Assoc
Background: Coagulation plays a role in ischemic heart disease (IHD). However, which
coagulation factors are targets of intervention is unclear. We assessed how genetically …
coagulation factors are targets of intervention is unclear. We assessed how genetically …
In vitro functional characterization of missense mutations in the LDLR gene
BACKGROUND: Mutations in the LDL receptor gene are the major cause of familial
hypercholesterolaemia (FH) but it has been previously shown that the simple finding of a …
hypercholesterolaemia (FH) but it has been previously shown that the simple finding of a …
Effects of coagulation Factor VII polymorphisms on the coronary artery disease in Japanese: Factor VII polymorphism and coronary disease
K Shimokata, T Kondo, M Ohno, K Takeshita… - Thrombosis research, 2002 - Elsevier
We investigated the relationships among Factor VII coagulant activity (FVIIc), genetic
polymorphisms of Factor VII (FVII) and coronary artery disease (CAD) in 380 unrelated …
polymorphisms of Factor VII (FVII) and coronary artery disease (CAD) in 380 unrelated …
Influence of exonic polymorphisms in the gene for LDL receptor-related protein (LRP) on risk of coronary artery disease
A Pocathikorn, B Granath, E Thiry, F Van Leuven… - Atherosclerosis, 2003 - Elsevier
The low density lipoprotein (LDL) receptor-related protein (LRP) is a multifunctional receptor
involved in numerous biological processes relevant to vascular biology including lipoprotein …
involved in numerous biological processes relevant to vascular biology including lipoprotein …
A novel single base deletion in the LDLR gene (211delG): effect on serum lipid profiles and the influence of other genetic polymorphisms in the ACE, APOE and APOB …
AJ Ward, M O'Kane, DP Nicholls, IS Young, NC Nevin… - Atherosclerosis, 1996 - Elsevier
A single base deletion (211delG) in the low density lipoprotein receptor (LDLR) gene was
shown to cause familial hypercholesterolaemia (FH) in a large family from Northern Ireland …
shown to cause familial hypercholesterolaemia (FH) in a large family from Northern Ireland …
LDL receptor cooperates with LDL receptor–related protein in regulating plasma levels of coagulation factor VIII in vivo
N Bovenschen, K Mertens, L Hu, LM Havekes… - Blood, 2005 - ashpublications.org
Low-density lipoprotein (LDL) receptor (LDLR) and LDLR-related protein (LRP) are
members of the LDLR family of endocytic receptors. LRP recognizes a wide spectrum of …
members of the LDLR family of endocytic receptors. LRP recognizes a wide spectrum of …
Polygenic risk score for low-density lipoprotein cholesterol is associated with risk of ischemic heart disease and enriches for individuals with familial …
Background: The clinical implications of a polygenic risk score (PRS) for LDL-C (low-density
lipoprotein cholesterol) are not well understood, both within the general population and …
lipoprotein cholesterol) are not well understood, both within the general population and …