Pepsin refluxate is considered a risk factor for laryngopharyngeal carcinogenesis. Non-
acidic pepsin was previously linked to an inflammatory and tumorigenic effect on …

Abstract Objective/Hypothesis: Laryngopharyngeal reflux (LPR) is thought to be a significant
risk factor for laryngeal squamous cell carcinoma (SCC), but causality has never been …

Outcome Objectives (1) Investigate the role of reflux, specifically pepsin, in
laryngopharyngeal carcinogenesis.(2) Evaluate effects of chronic pepsin exposure on cell …

Background Extra-esophageal carcinogenesis has been widely discussed in relation to the
chronic effects of laryngopharyngeal reflux and most prominently with pepsin historically …

Objective Laryngopharyngeal reflux (LPR) is a common affliction that contributes to
laryngeal inflammation, symptoms that impact quality of life, and life‐threatening illnesses …

Objectives: The current study was performed to determine the presence of pepsin in saliva
and laryngeal tissue among participants with benign and malignant laryngeal neoplasms …

Pepsin plays an important role in laryngopharyngeal reflux (LPR), a risk factor for the
development of hypopharyngeal squamous cell carcinomas (HPSCC). However, the role of …

Introduction. Gastroesophageal reflux has been associated with chronic inflammatory
diseases and may be a cause of airway remodelling. Aspiration of gastric fluids may cause …

Background Laryngopharyngeal reflux (LPR), with its increasing morbidity, is attracting
considerable attention. In recent years, the causal role between LPR and laryngeal …

Objective: To investigate the contribution of pepsin to inflammation attributed to nonacidic
gastric reflux via analysis of inflammatory cytokine and cytokine receptor gene expression in …