[HTML][HTML] The molecular mechanisms of the relationship between insulin resistance and Parkinson's disease pathogenesis

VA Ruiz-Pozo, R Tamayo-Trujillo, S Cadena-Ullauri… - Nutrients, 2023 - mdpi.com
Parkinson's disease (PD) is a degenerative condition resulting from the loss of dopaminergic
neurons. This neuronal loss leads to motor and non-motor neurological symptoms. Most PD …

Insulin resistance and Parkinson's disease: a new target for disease modification?

D Athauda, T Foltynie - Progress in neurobiology, 2016 - Elsevier
There is growing evidence that patients with Type 2 diabetes have an increased risk of
developing Parkinson's disease and share similar dysregulated pathways suggesting …

The relevance of insulin action in the dopaminergic system

F Fiory, G Perruolo, I Cimmino, S Cabaro… - Frontiers in …, 2019 - frontiersin.org
The advances in medicine, together with lifestyle modifications, led to a rising life
expectancy. Unfortunately, however, aging is accompanied by an alarming boost of age …

Therapies modulating insulin resistance in Parkinson's disease: a cross talk

T Sharma, D Kaur, AK Grewal, TG Singh - Neuroscience Letters, 2021 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder linked with aging and primarily
involves dopaminergic neuronal loss in the substantia nigra pars compacta (SNpc). The …

Deciphering intertwined Molecular pathways underlying metabolic syndrome leading to Parkinson's Disease

R Soni, J Shah - ACS Chemical Neuroscience, 2022 - ACS Publications
Parkinson's disease (PD) is a neurodegenerative disorder that gradually develops over time
in a progressive manner. The main culprit behind the disease pathology is dopaminergic …

Type 2 diabetes (T2DM) and Parkinson's disease (PD): a mechanistic approach

SS Sabari, K Balasubramani, M Iyer… - Molecular …, 2023 - Springer
Growing evidence suggest that there is a connection between Parkinson's disease (PD) and
insulin dysregulation in the brain, whilst the connection between PD and type 2 diabetes …

Convergent molecular pathways in type 2 diabetes mellitus and parkinson's disease: insights into mechanisms and pathological consequences

S Xxxx, MH Ahmad, L Rani, AC Mondal - Molecular Neurobiology, 2022 - Springer
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by
hyperglycemic conditions. A higher risk of developing Parkinson's disease (PD) in patients …

Insulin resistance promotes Parkinson's disease through aberrant expression of α-synuclein, mitochondrial dysfunction, and deregulation of the polo-like kinase 2 …

CT Hong, KY Chen, W Wang, JY Chiu, D Wu, TY Chao… - Cells, 2020 - mdpi.com
Background: Insulin resistance (IR), considered a hallmark of diabetes at the cellular level, is
implicated in pre-diabetes, results in type 2 diabetes, and negatively affects mitochondrial …

Insulin signaling pathway and related molecules: role in neurodegeneration and Alzheimer's disease

A Akhtar, SP Sah - Neurochemistry international, 2020 - Elsevier
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. Its major
pathological hallmarks, neurofibrillary tangles (NFT), and amyloid-β plaques can result from …

The association between type 2 diabetes mellitus and Parkinson's disease

JLY Cheong, E de Pablo-Fernandez… - Journal of …, 2020 - content.iospress.com
In recent years, an emerging body of evidence has forged links between Parkinson's
disease (PD) and type 2 diabetes mellitus (T2DM). In observational studies, those with …