Ascent to high altitude is associated with a fall in the partial pressure of inspired oxygen
(hypobaric hypoxia). For oxidative tissues such as skeletal muscle, resultant cellular hypoxia …

Modifications of skeletal muscle mitochondria following exposure to high altitude (HA) are
generally studied by morphological examinations and biochemical analysis of expression …

At high altitude, barometric pressure falls and with it inspired, potentially compromising O2
delivery to the tissues. With sufficient acclimatisation, the erythropoietic response increases …

Many disease states are associated with regional or systemic hypoxia. The study of healthy
individuals exposed to high-altitude hypoxia offers a way to explore hypoxic adaptation …

In most tissues of the body, cellular ATP production predominantly occurs via mitochondrial
oxidative phosphorylation of reduced intermediates, which are in turn derived from …

ABSTRACT PASIAKOS, SM, CE BERRYMAN, CT CARRIGAN, AJ YOUNG, and JW
CARBONE. Muscle Protein Turnover and the Molecular Regulation of Muscle Mass during …

Key points Mitochondrial function changes over time at high altitudes, but the potential
benefits of these changes for hypoxia resistance remains unclear. We used high‐altitude …

Metabolic responses to hypoxia play important roles in cell survival strategies and disease
pathogenesis in humans. However, the homeostatic adjustments that balance changes in …

Comparative physiology studies of high-altitude species provide an exceptional opportunity
to understand naturally evolved mechanisms of hypoxia resistance. Aerobic capacity …

Abstract Flueck, Martin. Plasticity of the muscle proteome to exercise at altitude. High Alt.
Med. Biol. 10: 183–193, 2009.—The ascent of humans to the summits of the highest peaks …