[HTML][HTML] The role of adipose tissue immune cells in obesity and low-grade inflammation

M Mraz, M Haluzik - Journal of Endocrinology, 2014 - joe.bioscientifica.com
Adipose tissue (AT) lies at the crossroad of nutrition, metabolism, and immunity; AT
inflammation was proposed as a central mechanism connecting obesity with its metabolic …

Innate immune cells in the adipose tissue

KJ Chung, M Nati, T Chavakis… - Reviews in Endocrine and …, 2018 - Springer
Immune cells are present in the adipose tissue (AT) and regulate its function. Under lean
conditions, immune cells predominantly of type 2 immunity, including eosinophils, M2-like …

[HTML][HTML] Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance

BC Lee, J Lee - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2014 - Elsevier
There is increasing evidence showing that inflammation is an important pathogenic mediator
of the development of obesity-induced insulin resistance. It is now generally accepted that …

[HTML][HTML] Adipose tissue immune cells in obesity, type 2 diabetes mellitus and cardiovascular diseases

A Cinkajzlová, M Mráz, M Haluzík - Journal of Endocrinology, 2022 - joe.bioscientifica.com
Immune cells are an inseparable component of adipose tissue intimately involved in most of
its functions. Physiologically, they regulate adipose tissue homeostasis, while in case of …

[HTML][HTML] Adipocytes, innate immunity and obesity: A mini-review

AM Blaszczak, A Jalilvand, WA Hsueh - Frontiers in immunology, 2021 - frontiersin.org
The role of adipose tissue (AT) inflammation in obesity and its multiple related-complications
is a rapidly expanding area of scientific interest. Within the last 30 years, the role of the …

[HTML][HTML] Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages

K Meijer, M de Vries, S Al-Lahham, M Bruinenberg… - PloS one, 2011 - journals.plos.org
Background Obesity promotes inflammation in adipose tissue (AT) and this is implicated in
pathophysiological complications such as insulin resistance, type 2 diabetes and …

The role of infiltrating immune cells in dysfunctional adipose tissue

TJ Guzik, DS Skiba, RM Touyz… - Cardiovascular …, 2017 - academic.oup.com
Adipose tissue (AT) dysfunction, characterized by loss of its homeostatic functions, is a
hallmark of non-communicable diseases. It is characterized by chronic low-grade …

Adipose tissue-resident immune cells: key players in immunometabolism

HS Schipper, B Prakken, E Kalkhoven… - Trends in Endocrinology & …, 2012 - cell.com
Adipose tissue (AT) plays a pivotal role in whole-body lipid and glucose homeostasis. AT
exerts metabolic control through various immunological mechanisms that instigated a new …

The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance

S Winer, DA Winer - Immunology and cell biology, 2012 - Wiley Online Library
Over the past decade, chronic inflammation in visceral adipose tissue (VAT) has gained
acceptance as a lead promoter of insulin resistance in obesity. A great deal of evidence has …

Adipose tissue as an immunological organ

RW Grant, VD Dixit - Obesity, 2015 - Wiley Online Library
Objective This review will focus on the immunological aspects of adipose tissue and its
potential role in development of chronic inflammation that instigates obesity‐associated …