Nuclear receptor Nur77 plays a pivotal role in immune regulation across various tissues,
influencing pro-inflammatory signaling pathways and cellular metabolism. While cellular …

Background The nuclear orphan receptor Nur77 (NR4A1, TR3, or NGFI-B) has been shown
to modulate the inflammatory response of macrophages. To further elucidate the role of …

Nur77 is a nuclear receptor that has been implicated as a regulator of inflammatory disease.
The expression of Nur77 increases upon stimulation of immune cells and is differentially …

Nurr1 is a member of the orphan nuclear receptor family NR4A (nuclear receptor subfamily 4
group A) that modulates inflammation in several cell lineages, both positively and …

The orphan nuclear receptor Nur77 is involved in diverse cellular processes such as
inflammation, proliferation, differentiation and survival. Stimuli like lipopolysaccharide (LPS) …

Background Nur77, an orphan member of the nuclear receptor superfamily, has been
implicated in the regulation of inflammation. However, the in vivo function of Nur77 remains …

The orphan nuclear receptor Nur77 is an immediate-early response gene that based on
tissue and cell context is implicated in a plethora of cellular processes, including …

Nur77, an orphan member of the nuclear receptor superfamily, plays critical roles in
inflammation and immunity. However, the role of Nur77 in tumor microenvironment remains …

Macrophage polarization is a process whereby macrophages develop a specific phenotype
and functional response to different pathophysiological stimuli and tissue environments. In …

Sepsis, a hyperinflammatory response that can result in multiple organ dysfunctions, is a
leading cause of mortality from infection. Here, we show that orphan nuclear receptor Nur77 …