Because clinical trials of pharmacological neuroprotective strategies in stroke have been
disappointing, attention has turned to the brain's own endogenous strategies for …

As clinical trials of pharmacological neuroprotective strategies in stroke have been
disappointing, attention has turned to the brain's own endogenous strategies for …

Ischemic conditioning is a form of endogenous protection induced by transient, subcritical
ischemia in a tissue. Organs with high sensitivity to ischemia, such as the heart, the brain …

The author reviews the protective effects of ischemic postconditioning, a recently emerging
strategy with broad implications in the search for new treatments in stroke and myocardial …

Ischemic postconditioning is a concept originally defined to contrast with that of ischemic
preconditioning. While both preconditioning and postconditioning confer a neuroprotective …

Ischemic postconditioning initially referred to a stuttering reperfusion performed immediately
after reperfusion, for preventing ischemia/reperfusion injury in both myocardial and cerebral …

Stroke is one of the leading causes of death and long-term serious disability. Current
therapeutic strategy is limited to thrombolytic agents, consequently, boosting endogenous …

Ischemic preconditioning involves a brief exposure to ischemia in order to develop a
tolerance to injurious effects of prolonged ischemia. The molecular mechanisms of …

Ischemic brain damage occurs through all age subgroups, ranging from the newborn to the
elderly, but with predominance in more aged brains either in animals or in humans. The …

Cerebral preconditioning constitutes the brain's adaptation to lethal ischemia when first
exposed to mild doses of a subtoxic stressor. The phenomenon of preconditioning has been …