YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression
SM Lyons, C Achorn, NL Kedersha… - Nucleic acids …, 2016 - academic.oup.com
Abstract Stress-induced angiogenin (ANG)-mediated tRNA cleavage promotes a cascade of
cellular events that starts with production of tRNA-derived stress-induced RNAs (tiRNAs) …
cellular events that starts with production of tRNA-derived stress-induced RNAs (tiRNAs) …
Angiogenin-induced tRNA fragments inhibit translation initiation
Angiogenin is a stress-activated ribonuclease that cleaves tRNA within anticodon loops to
produce tRNA-derived stress-induced fragments (tiRNAs). Transfection of natural or …
produce tRNA-derived stress-induced fragments (tiRNAs). Transfection of natural or …
Angiogenin-induced tRNA-derived stress-induced RNAs promote stress-induced stress granule assembly
Angiogenin (ANG) is a secreted ribonuclease that cleaves tRNA to initiate a stress-response
program in mammalian cells. Here we show that ANG inhibits protein synthesis and …
program in mammalian cells. Here we show that ANG inhibits protein synthesis and …
RTCB complex regulates stress-induced tRNA cleavage
Y Akiyama, Y Takenaka, T Kasahara, T Abe… - International Journal of …, 2022 - mdpi.com
Under stress conditions, transfer RNAs (tRNAs) are cleaved by stress-responsive RNases
such as angiogenin, generating tRNA-derived RNAs called tiRNAs. As tiRNAs contribute to …
such as angiogenin, generating tRNA-derived RNAs called tiRNAs. As tiRNAs contribute to …
G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments
Angiogenin (ANG) is a stress-activated ribonuclease that promotes the survival of motor
neurons. Ribonuclease inactivating point mutations are found in a subset of patients with …
neurons. Ribonuclease inactivating point mutations are found in a subset of patients with …
tiRNAs: A novel class of small noncoding RNAs that helps cells respond to stressors and plays roles in cancer progression
Abstract tRNA‐derived stress‐induced RNAs (tiRNAs), important components of tRNA‐
derived fragments, are gaining popularity for their functions as small noncoding RNAs …
derived fragments, are gaining popularity for their functions as small noncoding RNAs …
Identification of RNA helicases with unwinding activity on angiogenin-processed tRNAs
A Drino, L König, C Capitanchik… - Nucleic Acids …, 2023 - academic.oup.com
Stress-induced tRNA fragmentation upon environmental insult is a conserved cellular
process catalysed by endonucleolytic activities targeting mature tRNAs. The resulting tRNA …
process catalysed by endonucleolytic activities targeting mature tRNAs. The resulting tRNA …
Angiogenin cleaves tRNA and promotes stress-induced translational repression
Stress-induced phosphorylation of eIF2α inhibits global protein synthesis to conserve
energy for repair of stress-induced damage. Stress-induced translational arrest is observed …
energy for repair of stress-induced damage. Stress-induced translational arrest is observed …
Isolation and initial structure-functional characterization of endogenous tRNA-derived stress-induced RNAs
Recent transcriptome-wide studies have identified a diverse pool of transfer RNA (tRNA)-
derived RNAs or tRNA-derived fragments (tRFs). Some of these RNAs have been …
derived RNAs or tRNA-derived fragments (tRFs). Some of these RNAs have been …
Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species
V Evdokimova, P Ruzanov, MS Anglesio… - … and cellular biology, 2006 - Taylor & Francis
YB-1 is a broad-specificity RNA-binding protein that is involved in regulation of mRNA
transcription, splicing, translation, and stability. In both germinal and somatic cells, YB-1 and …
transcription, splicing, translation, and stability. In both germinal and somatic cells, YB-1 and …