Changes in m6A RNA methylation contribute to heart failure progression by modulating translation

T Berulava, E Buchholz, V Elerdashvili… - European journal of …, 2020 - Wiley Online Library
Aims Deregulation of epigenetic processes and aberrant gene expression are important
mechanisms in heart failure. Here we studied the potential relevance of m6A RNA …

[HTML][HTML] Alteration of m6A RNA methylation in heart failure with preserved ejection fraction

B Zhang, Y Xu, X Cui, H Jiang, W Luo… - Frontiers in …, 2021 - frontiersin.org
Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous
disease, in which its pathogenesis is very complex and far from defined. Here, we explored …

mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification

R Kumari, P Ranjan, ZG Suleiman… - Cardiovascular …, 2022 - academic.oup.com
Among several known RNA modifications, N6‐methyladenosine (m6A) is the most studied
RNA epitranscriptomic modification and controls multiple cellular functions during …

m6A-mRNA methylation regulates cardiac gene expression and cellular growth

V Kmietczyk, E Riechert, L Kalinski… - Life science …, 2019 - life-science-alliance.org
Conceptually similar to modifications of DNA, mRNAs undergo chemical modifications,
which can affect their activity, localization, and stability. The most prevalent internal …

The N6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy

LE Dorn, L Lasman, J Chen, X Xu, TJ Hund… - Circulation, 2019 - Am Heart Assoc
Background: N 6-Methyladenosine (m6A) methylation is the most prevalent internal
posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation …

[HTML][HTML] Emerging roles and mechanism of m6A methylation in cardiometabolic diseases

Z Xu, B Lv, Y Qin, B Zhang - Cells, 2022 - mdpi.com
Cardiometabolic diseases (CMDs) are currently the leading cause of death and disability
worldwide, and their underlying regulatory mechanisms remain largely unknown. N6 …

[HTML][HTML] Role of m6A RNA methylation in cardiovascular disease

Y Qin, L Li, E Luo, J Hou, G Yan… - International …, 2020 - spandidos-publications.com
Abstract N6‑methyladenosine (m6A) is the most prevalent and abundant type of internal post‑
transcriptional RNA modification in eukaryotic cells. Multiple types of RNA, including …

N6-Adenosine Methylation (m6A) RNA Modification: an Emerging Role in Cardiovascular Diseases

Y Chen, X Ouyang, X Yu, P Novák, L Zhou… - Journal of …, 2021 - Springer
Abstract N6-methyladenosine (m 6 A) is the most abundant and prevalent epigenetic
modification of mRNA in mammals. This dynamic modification is regulated by m 6 A …

[HTML][HTML] METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury

L Wang, J Wang, P Yu, J Feng, G Xu, X Zhao… - Nature …, 2022 - nature.com
RNA m6A modification is the most widely distributed RNA methylation and is closely related
to various pathophysiological processes. Although the benefit of regular exercise on the …

[HTML][HTML] m6A RNA methylation in cardiovascular diseases

S Wu, S Zhang, X Wu, X Zhou - Molecular Therapy, 2020 - cell.com
Cardiovascular diseases (CVDs) remain the leading cause of death and disability
worldwide, despite marked improvements in prevention, diagnosis, and early intervention …