Positively Charged-Amylose-Entangled Au-Nanoparticles Acting as Protein Carriers and Potential Adjuvants to SARS-CoV-2 Subunit Vaccines

B Fan, J Gu, B Deng, W Guo, S Zhang… - ACS Applied Materials …, 2023 - ACS Publications
The COVID-19 pandemic continues to spread worldwide. To protect and control the spread
of SARS-CoV-2, varieties of subunit vaccines based on spike (S) proteins have been …

Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates

L He, X Lin, Y Wang, C Abraham, C Sou, T Ngo… - Science …, 2021 - science.org
Vaccination against SARS-CoV-2 provides an effective tool to combat the COVID-19
pandemic. Here, we combined antigen optimization and nanoparticle display to develop …

Subunit nanovaccine with potent cellular and mucosal immunity for COVID-19

L Liu, Z Liu, H Chen, H Liu, Q Gao, F Cong… - ACS applied bio …, 2020 - ACS Publications
To combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic,
we formulated the S1 subunit of the virus with two adjuvants, amphiphilic adjuvant …

SARS-CoV-2 Nanovaccine Composed of Microfluidic-Produced Gold Nanoparticles Induces Neutralizing Immune Responses

NC Dalibera, MJ Rodrigues-Jesus… - ACS Applied Nano …, 2023 - ACS Publications
The pursuit of effective and safe vaccines against severe acute respiratory syndrome caused
by SARS-CoV-2 has posed a significant challenge for science in recent years, allowing the …

Two-component nanoparticle vaccine displaying glycosylated spike S1 domain induces neutralizing antibody response against SARS-CoV-2 variants

L van Oosten, JJ Altenburg, C Fougeroux… - MBio, 2021 - Am Soc Microbiol
Vaccines pave the way out of the SARS-CoV-2 pandemic. Besides mRNA and adenoviral
vector vaccines, effective protein-based vaccines are needed for immunization against …

Double-layered N-S1 protein nanoparticle immunization elicits robust cellular immune and broad antibody responses against SARS-CoV-2

R Li, Z Chang, H Liu, Y Wang, M Li, Y Chen… - Journal of …, 2024 - Springer
Background The COVID-19 pandemic is a persistent global threat to public health. As for the
emerging variants of SARS-CoV-2, it is necessary to develop vaccines that can induce …

SARS‐CoV‐2 Spike Stem Protein Nanoparticles Elicited Broad ADCC and Robust Neutralization against Variants in Mice

Y Ma, Y Wang, C Dong, GX Gonzalez, W Zhu, J Kim… - Small, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has caused the global
pandemic. The virus is rapidly evolving, characterized by the emergence of several major …

Protein-based nano-vaccines against SARS-CoV-2: Current design strategies and advances of candidate vaccines

D Wang, Y Yuan, B Liu, ND Epstein, Y Yang - International Journal of …, 2023 - Elsevier
The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has shaken the global health system …

Rapid development of SARS-CoV-2 spike protein receptor-binding domain self-assembled nanoparticle vaccine candidates

YF Kang, C Sun, Z Zhuang, RY Yuan, Q Zheng, JP Li… - ACS …, 2021 - ACS Publications
The coronavirus disease pandemic of 2019 (COVID-19) caused by the novel SARS-CoV-2
coronavirus resulted in economic losses and threatened human health worldwide. The …

Self-Assembling Sulfated Lactobacillus Exopolysaccharide Nanoparticles as Adjuvants for SARS-CoV-2 Subunit Vaccine Elicit Potent Humoral and Cellular Immune …

S Zhang, W Fan, C Ding, M Zhang, S Liu… - … Applied Materials & …, 2024 - ACS Publications
Coronavirus disease 2019 (COVID-19) has caused a global pandemic since its onset in
2019, and the development of effective vaccines for severe acute respiratory syndrome …