Abstract Nearly 60 years ago Seymour Kety proposed that research on genetics and brain
pathology, but not on neurochemistry, would ultimately lead to an understanding of the …

Many structural alterations occur in the brain in schizophrenia (see Harrison 1999, Shapiro
1993), and the prevailing hypothesis is that these are caused by an anomaly in brain …

Contrary to the notion that neurology but not psychiatry is the domain of disorders evincing
structural brain alterations, it is now clear that there are subtle but consistent …

In the past century, the finding of ventricular enlargement in structural brain imaging studies
of schizophrenia has stimulated interest in the question of whether this disorder may involve …

The most notable observation about the brain of a schizophrenia subject, including the
prefrontal cortex, is its normal appearance. This absence of any discernible morphologic …

Structural neuroimaging studies have provided some of the most consistent evidence for
brain abnormalities in schizophrenia. Since the initial computed tomography study by …

The literature on alterations in brain structure and function in schizophrenia, particularly in
relationship to impairments in cognitive, motor, and affective functions, has made it …

Despite a hundred years' research, the neuropathology of schizophrenia remains obscure.
However, neither can the null hypothesis be sustained—that it is afunctional'psychosis, a …

Neuropathological studies have provided clues as to the cellular and molecular correlates of
the structural differences in schizophrenia that have been identified by brain imaging. There …

Neuroimaging and electrophysiological investigations have demonstrated numerous
differences in brain morphology and function of chronic schizophrenia patients compared to …