Dietary tomato inhibits angiogenesis in TRAMP prostate cancer but is not protective with a Western-style diet in this pilot study

CC Applegate, MR Lowerison, E Hambley, P Song… - Scientific reports, 2021 - nature.com
Prostate cancer (PCa) remains the second most diagnosed cancer worldwide. Higher body
weight is associated with chronic inflammation, increased angiogenesis, and treatment …

Impact of dietary tomato intake on prostate cancer throughout the course of disease development and progression in a transgenic mouse model

CC Applegate - 2020 - ideals.illinois.edu
Despite decreasing trends of overall diagnosis, prostate cancer (PCa) is the most commonly
diagnosed male cancer in the United States. However, the decrease in total and early stage …

Dietary tomato, but not lycopene supplementation, impacts molecular outcomes of castration-resistant prostate cancer in the TRAMP model (P05-015-19)

C Applegate, J Rowles III, R Miller, M Wallig… - Current developments in …, 2019 - Elsevier
Objectives The objective was to determine whether dietary tomato or lycopene
supplementation impacted the expression of biomarkers associated with aggressive tumors …

A dietary tomato supplement prevents prostate cancer in TRAMP mice

T Pannellini, M Iezzi, M Liberatore, F Sabatini… - Cancer prevention …, 2010 - AACR
Transgenic adenocarcinoma of the mouse prostate (TRAMP) is a model for progressive
prostate cancer that mirrors the stages of the human form. In this study, the effects of a diet …

[HTML][HTML] Dietary tomato or lycopene do not reduce castration-resistant prostate cancer progression in a murine model

JL Rowles III, JW Smith, CC Applegate, MA Wallig… - The Journal of …, 2020 - Elsevier
Background: Dietary tomato products or lycopene protect against prostate carcinogenesis,
but their impact on the emergence of castration-resistant prostate cancer (CRPC) is …

Dietary tomato and lycopene impact androgen signaling-and carcinogenesis-related gene expression during early TRAMP prostate carcinogenesis

L Wan, HL Tan, JM Thomas-Ahner, DK Pearl… - Cancer Prevention …, 2014 - AACR
Consumption of tomato products containing the carotenoid lycopene is associated with a
reduced risk of prostate cancer. To identify gene expression patterns associated with early …

The interactions of dietary tomato powder and soy germ on prostate carcinogenesis in the TRAMP model

KE Zuniga, SK Clinton, JW Erdman Jr - Cancer prevention research, 2013 - AACR
The interactions between bioactive-rich food components within a complex human diet for
the inhibition of prostate carcinogenesis are largely unknown and difficult to quantify in …

Tomato-based food products for prostate cancer prevention: what have we learned?

HL Tan, JM Thomas-Ahner, EM Grainger… - Cancer and Metastasis …, 2010 - Springer
Evidence derived from a vast array of laboratory studies and epidemiological investigations
have implicated diets rich in fruits and vegetables with a reduced risk of certain cancers …

[HTML][HTML] Dietary tomato consumption and the risk of prostate cancer: a meta-analysis

J Luo, D Ke, Q He - Frontiers in Nutrition, 2021 - frontiersin.org
Objective: Several epidemiological studies have linked tomato products consumption with
prostate cancer risk; however, the findings yielded inconsistent results. The aim of the …

Tomato paste alters NF-κB and cancer-related mRNA expression in prostate cancer cells, xenografts, and xenograft microenvironment

M Kolberg, S Pedersen, NE Bastani, H Carlsen… - Nutrition and …, 2015 - Taylor & Francis
Tomatoes may protect against prostate cancer development, possibly through targeting
signaling pathways such as nuclear factor-κB (NF-κB). We investigated whether tomato …