The purpose of the article To identify novel small molecule antagonists of Urotensin II
receptor with acceptable pharmacological profile. Materials and methods Structure-activity …

High throughput screening of the corporate compound collection led to the discovery of a
novel series of substituted aminoalkoxybenzyl pyrrolidines as human urotensin-II receptor …

A series of 2-aminomethyl piperidines has been discovered as novel urotensin-II receptor
antagonists. The synthesis, initial structure-activity relationships, and optimization of the …

SAR exploration of the central diamine, benzyl, and terminal aminoalkoxy regions of the N-
cyclic azaalkyl benzamide series led to the identification of very potent human urotensin-II …

A series of novel isochromanone based urotensin II receptor agonists have been
synthesized and evaluated for their activity using a functional cell based assay (R-SAT) …

Six different series of nonpeptidic urotensin II receptor agonists have been synthesized and
evaluated for their agonistic activity in a cell-based assay (R-SAT). The compounds are ring …

The preparation and SAR profile of thieno [3, 2-b] pyridinyl urea derivatives as novel and
potent urotensin-II receptor antagonists are described. An activity optimization study, probing …

High throughput screening of our compound collection led to the discovery of a novel series
of N-alkyl-5H-pyrido [4, 3-b] indol-1-amines as urotensin-II receptor antagonists. Synthesis …

A series of analogs of the non-peptidic urotensin II receptor agonist N-[1-(4-chlorophenyl)-3-
(dimethylamino) propyl]-4-phenylbenzamide (FL104) has been synthesized and evaluated …

Members of a series of benzo [b] thiophene-2-carboxamide derivatives, possessing an N-(1-
(3-bromo-4-(piperidin-4-yloxy) benzyl) piperidin-4-yl) group, were synthesized and …