Aging induces a progressive decline in vasoconstrictor responses in central and peripheral
arteries. This study investigated the hypothesis that vascular smooth muscle (VSM) …

Arterial aging results in a progressive reduction in elasticity of the vessel wall and an
impaired ability of aged blood vessels to control local blood flow and pressure. Recently, a …

We tested the hypothesis that aging decreases endothelium-dependent vasodilation in feed
arteries perfusing rat skeletal muscle. In addition, we tested the hypothesis that attenuated …

Although advancing age is often associated with attenuated skeletal muscle blood flow and
skeletal muscle feed arteries (SMFAs) have been recognized to play a regulatory role in the …

We tested the hypothesis that short-term increases in intraluminal pressure improve
endothelium-dependent dilation and increase endothelial nitric oxide (NO) synthase (eNOS) …

We tested the hypothesis that impaired nitric oxide (NO)-mediated, endothelium-dependent
dilation in aged soleus muscle feed arteries (SFA) is due to an age-related decline in the …

Key structural and functional properties of the skeletal muscle vasculature that underlie
diminished vascular conductance with ageing remain obscure. The purpose of this …

Blood flow capacity in skeletal muscle declines with age. Reduced blood flow capacity may
be related to decline in the maximal vasodilatory capacity of the resistance vasculature. This …

Humans are active creatures, yet physical activity and activity tolerance decline over the life
span. One prevailing theme in the literature to account for a portion of the reduced activity …

Aging is associated with an altered ability to match oxygen delivery (Qo2) to consumption
(V̇o2) in skeletal muscle and differences in the temporal profile of vasodilation may provide …