In recent years, tissue engineering has been developing rapidly, manifesting itself in the
emergence of applied studies within clinical practice and fundamental research devoted to …

Cell seeding is a critical step in tissue engineering. A high number of cells evenly distributed
in scaffolds after seeding are associated with a more functional tissue culture. Furthermore …

Scaffolds engineered for in vitro tissue engineering consist of multiple pores where cells can
migrate along with nutrient-rich culture medium. The presence of the nutrient medium …

Cell proliferation within a fluid-filled porous tissue-engineering scaffold depends on a
sensitive choice of pore geometry and flow rates: regions of high curvature encourage cell …

In this thesis, a series of mathematical models suitable for describing biological tissue
growth are developed. The motivation for this work is a bioreactor system which provides …

In vitro tissue engineering is emerging as a potential tool to meet the high demand for
replacement tissue, caused by the increased incidence of tissue degeneration and damage …

In this work, we present a mathematical model of cell growth in the pores of a perfusion
bioreactor through which a nutrient solution is pumped. We have developed a 2-D vertex …

A contemporary procedure to grow artificial tissue is to seed cells onto a porous biomaterial
scaffold and culture it within a perfusion bioreactor to facilitate the transport of nutrients to …

The main challenge in engineered cartilage consists in understanding and controlling the
growth process towards a functional tissue. Mathematical and computational modelling can …

A biological tissue in general is formed by cells, extracellular matrix (ECM) and fluids.
Consequently, its overall material behaviour results from its components and their …