The clinical diagnosis of Parkinson's disease rests on the identification of the characteristics
related to dopamine deficiency that are a consequence of degeneration of the substantia …

Neuromodulatory or even neuroprotective therapy could soon be available for Parkinson's
disease (PD), raising the question of how we should define and measure disease …

Non-motor symptoms (NMS) of Parkinson's disease can be predominant as the disease
advances, thereby constituting a major source of disease burden for patients and caregivers …

Recent findings question our present understanding of Parkinson's disease and suggest that
new research criteria for the diagnosis of Parkinson's disease are needed, similar to those …

Parkinson's disease is a neurological disorder with evolving layers of complexity. It has long
been characterised by the classical motor features of parkinsonism associated with Lewy …

With the hope that disease-modifying treatments could target the molecular basis of
Parkinson's disease, even before the onset of symptoms, we propose a biologically based …

Parkinson's disease is the most common serious movement disorder in the world, affecting
about 1% of adults older than 60 years. The disease is attributed to selective loss of neurons …

Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …

Neurodegeneration in Parkinson's disease starts years before a clinical diagnosis can be
reliably made. The prediagnostic phase of the disease offers a window of opportunity in …

Over history, diseases have appeared and disappeared, or have increased or decreased in
frequency. These epidemiological trends have occurred more dramatically for infectious …