ABSTRACT T cell exhaustion and loss of memory potential occur during many chronic viral
infections and cancer. We investigated when during chronic viral infection virus-specific CD8 …

Clearance of primary infection often leads to the development of highly functional memory T
cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections …

Although previous studies have demonstrated delayed viral clearance and blunted effector T
cell responses in aged mice during infection, memory CD8 T cells and especially secondary …

Abstract C D8 T-cell responses play an important role in protection against intracellular
pathogens. Memory CD8 T cells mediate rapid clearance of pathogens upon secondary …

Efficient maintenance of memory CD8 T cells is central to long-term protective immunity. IL-7–
and IL-15–driven homeostatic proliferation is essential for long-term memory CD8 T cell …

Numerous microbes establish persistent infections, accompanied by antigen-specific CD8 T
cell activation. Pathogen-specific T cells in chronically infected hosts are often …

Memory CD8 T cells are an important component of protective immunity against viral
infections, and understanding their development will aid in the design of optimal vaccines …

Viral infections often induce potent CD8 T cell responses that play a key role in antiviral
immunity. After viral clearance, the vast majority of the expanded CD8 T cells undergo …

CD8 T cells are pivotal for the control of many intracellular pathogens, and besides their role
in immediate control of infections, CD8 T cells have the capacity to differentiate into long …

Memory T cells can persist for extended periods in the absence of antigen, and long-term T
cell immunity is often seen after acute infections. Paradoxically, there have been …