Cervical cancer is the most common gynecologic cancer, etiologically related to persistent
infection of human papillomavirus (HPV). Both the host innate immunity system and the …

Cervical cancer remains the second leading cause of gynecologic cancer-related mortality
among women worldwide. STING (stimulator of interferon genes) was reported to be …

Ovarian cancer is the most lethal malignant tumor of female reproductive system. It is well-
known that induction of STING-mediated type I interferons can enhance the resultant …

Background Stimulator of interferon genes (STING) is an innate immune sensor of
cytoplasmic double-stranded DNA originating from microorganisms and host cells. The …

The negative role of the activated stimulator of IFN genes (STING) has been uncovered in
autoinflammatory disease and cancer. However, the role of STING in virus-related …

ABSTRACT Activation of STimulator of INterferon Genes (STING) is important for induction of
anti-tumor immunity. A dysfunctional STING pathway is observed in multiple cancer types …

The incidence of human papillomavirus–positive (HPV+) head and neck squamous cell
carcinoma (HNSCC) has surpassed that of cervical cancer and is projected to increase …

Cellular infections by DNA viruses trigger innate immune responses mediated by DNA
sensors. The cyclic GMP–AMP synthase (cGAS)‐stimulator of interferon gene (STING) …

Activating stimulator of interferon genes to turn immunologically refractive cold tumor hot is
an exciting therapeutic approach to increase the clinical responsiveness of some human …

Objectives The intracellular DNA sensor stimulator of interferon genes (STING) has recently
been shown to play a vital role in anti-viral and anti-tumor immune responses stimulating …