Drug-associated dysfunction of mitochondria is believed to play a role in the etiology of the
various adverse symptoms that occur in human immunodeficiency virus (HIV)-infected …

Background Some nucleoside/nucleotide reverse transcriptase inhibitor (NRTI)
combinations cause additive or synergistic interactions in vitro and in vivo. Methods We …

This review is intended to provide understanding of the function of mitochondria, the
advantages and disadvantages of available techniques for assessing mitochondrial function …

Nucleoside reverse transcriptase inhibitors (NRTIs) in combination with other antiretrovirals
(HAART) are critical in current AIDS therapy, but mitochondrial side effects have come to …

Nucleoside reverse transcriptase inhibitors (NRTIs) remain the cornerstone of highly active
antiretroviral therapy (HAART) combination regimens. However, it has been known for some …

Tenofovir, used in combination with other antiretroviral agents, is an effective therapy for HIV
infection. Although large clinical studies and post-marketing data support a benign renal …

The introduction of newer and more potent agents has diverted attention away from the
importance of nucleoside analogue reverse transcriptase inhibitors (NRTIs) in modern …

Mitochondrial dysfunction has been associated with long-term toxicities of human
immunodeficiency virus (HIV) therapy, particularly with the nucleoside analog reverse …

Background Tenofovir (TDF) exposure has been associated with renal dysfunction.
Mitochondrial nephrotoxicity was investigated as an underlying mechanism. Given the …

OBJECTIVE: This paper reviews the function of the mitochondria and the mechanisms by
which nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) cause …