Chronic administration of the histamine H3 receptor agonist immepip decreases l-Dopa-induced dyskinesias in 6-hydroxydopamine-lesioned rats
A Avila-Luna, C Ríos, A Gálvez-Rosas, S Montes… - …, 2019 - Springer
Abstract Rationale Histamine H 3 receptors (H 3 Rs) are co-expressed with dopamine D 1
receptors (D 1 Rs) by striato-nigral medium spiny GABAergic neurons, where they …
receptors (D 1 Rs) by striato-nigral medium spiny GABAergic neurons, where they …
Histamine H3 receptor ligands modulate L-dopa-evoked behavioral responses and L-dopa-derived extracellular dopamine in dopamine-denervated rat striatum
P Nowak, A Bortel, J Dabrowska, I Biedka… - Neurotoxicity …, 2008 - Springer
To explore a recently established association between histaminergic and dopaminergic
neuronal phenotypic systems in brain, we determined the effect of the respective …
neuronal phenotypic systems in brain, we determined the effect of the respective …
Histamine H3 receptor agonist-and antagonist-evoked vacuous chewing movements in 6-OHDA-lesioned rats occurs in an absence of change in microdialysate …
P Nowak, J Dąbrowska, A Bortel, I Biedka… - European journal of …, 2006 - Elsevier
In rats lesioned neonatally with 6-hydroxydopamine (6-OHDA), repeated treatment with SKF
38393 (1-phenyl-2, 3, 4, 5-tetrahydro-(1H)-3-benzazepine-7, 8-diol), a dopamine D1/D5 …
38393 (1-phenyl-2, 3, 4, 5-tetrahydro-(1H)-3-benzazepine-7, 8-diol), a dopamine D1/D5 …
Chronic H3R activation reduces L-Dopa-induced dyskinesia, normalizes cortical GABA and glutamate levels, and increases striatal dopamine D1R mRNA …
A Avila-Luna, A Gálvez-Rosas, A Aguirre-Pérez… - …, 2023 - Springer
Rationale Dyskinesias induced by L-3, 4-dihydroxyphenylalanine, L-Dopa (LIDs), are the
major complication in the pharmacological treatment of Parkinson's disease. LIDs induce …
major complication in the pharmacological treatment of Parkinson's disease. LIDs induce …
Histamine H3 receptor activation prevents dopamine D1 receptor-mediated inhibition of dopamine release in the rat striatum: a microdialysis study
A Alfaro-Rodriguez, M Alonso-Spilsbury… - Neuroscience …, 2013 - Elsevier
Abstract Histamine H 3 receptors (H 3 Rs) co-localize with dopamine (DA) D 1 receptors (D
1 Rs) on striatal medium spiny neurons and functionally antagonize D 1 R-mediated …
1 Rs) on striatal medium spiny neurons and functionally antagonize D 1 R-mediated …
Histamine H3 receptor regulates sensorimotor gating and dopaminergic signaling in the striatum
JK Vanhanen, S Nuutinen, M Tuominen… - Journal of Pharmacology …, 2016 - ASPET
The brain histamine system has been implicated in regulation of sensorimotor gating deficits
and in Gilles de la Tourette syndrome. Histamine also regulates alcohol reward and …
and in Gilles de la Tourette syndrome. Histamine also regulates alcohol reward and …
Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function
The striatum contains a high density of histamine H3 receptors, but their role in striatal
function is poorly understood. Previous studies have demonstrated antagonistic interactions …
function is poorly understood. Previous studies have demonstrated antagonistic interactions …
Histamine H3 receptor antagonist JNJ-39220675 modulates locomotor responses but not place conditioning by dopaminergic drugs
J Vanhanen, M Kinnunen, S Nuutinen, P Panula - Psychopharmacology, 2015 - Springer
Rationale Brain histaminergic system is involved in the regulation of the dopaminergic
circuitry. The role of histamine H3 receptor (H3R) in behaviors linked to amphetamine …
circuitry. The role of histamine H3 receptor (H3R) in behaviors linked to amphetamine …
The histamine H3 receptor modulates dopamine D2 receptor–dependent signaling pathways and mouse behaviors
J Xu, C Pittenger - Journal of Biological Chemistry, 2023 - ASBMB
The histamine H3 receptor (H3R) is highly enriched in the spiny projection neurons (SPNs)
of the striatum, in both the D1 receptor (D1R)–expressing and D2 receptor (D2R) …
of the striatum, in both the D1 receptor (D1R)–expressing and D2 receptor (D2R) …
Contribution of the striatum to the effects of 5‐HT1A receptor stimulation in L‐DOPA‐treated hemiparkinsonian rats
Clinical and experimental studies implicate the use of serotonin (5‐HT) 1A receptor agonists
for the reduction of l‐3, 4‐dihydroxyphenylalanine (L‐DOPA)‐induced dyskinesia (LID) …
for the reduction of l‐3, 4‐dihydroxyphenylalanine (L‐DOPA)‐induced dyskinesia (LID) …