Intestinal accumulation of microbiota-produced succinate caused by loss of microRNAs leads to diarrhea in weanling piglets

X Zhou, Y Liu, X Xiong, J Chen, W Tang, L He… - Gut …, 2022 - Taylor & Francis
Diarrheal disease is a common health problem with complex causality. Although diarrhea is
accompanied by disturbances in microbial diversity, how gut microbes are involved in the …

Fecal Microbial Structure and Metabolic Profile in Post-Weaning Diarrheic Piglets

X Zheng, K Nie, Y Xu, H Zhang, F Xie, L Xu, Z Zhang… - Genes, 2023 - mdpi.com
(1) Background: Piglet diarrhea is one of the most serious diseases in pigs and has brought
great economic losses to the pig industry. Alteration of the gut microbiota is an important …

[HTML][HTML] Fecal miR-142a-3p from dextran sulfate sodium-challenge recovered mice prevents colitis by promoting the growth of Lactobacillus reuteri

L He, X Zhou, Y Liu, L Zhou, F Li - Molecular Therapy, 2022 - cell.com
Feces are enriched with microRNAs (miRNAs) that shape the gut microbiota. These miRNAs
are differentially expressed in the feces of healthy and diseased subjects. However, whether …

Multi-omics reveal mechanisms of high enteral starch diet mediated colonic dysbiosis via microbiome-host interactions in young ruminant

C Jin, S Wu, Z Liang, J Zhang, X Lei, H Bai, G Liang… - Microbiome, 2024 - Springer
Background Although rumen development is crucial, hindgut undertakes a significant role in
young ruminants' physiological development. High-starch diet is usually used to accelerate …

Lower abundance of Bacteroides and metabolic dysfunction are highly associated with the post-weaning diarrhea in piglets

W Ren, B Yu, J Yu, P Zheng, Z Huang, J Luo… - Science China Life …, 2022 - Springer
Growing evidences show a direct link between diarrhea and disorders of gut microbiota in
pigs. However, whether there are microbial markers associated with post-weaning diarrhea …

Succinate communicates pro-inflammatory signals to the host and regulates bile acid enterohepatic metabolism in a pig model

X Li, Y Ren, G Huang, R Zhang, Y Zhang, W Zhu… - Food & Function, 2022 - pubs.rsc.org
Succinate is produced by both the host and microbiota with pleiotropic functions in the
modulation of intestinal inflammation and metabolic homeostasis, but the mechanisms …

Metagenomic and metabolomic analyses reveal the role of gut microbiome-associated metabolites in diarrhea calves

Z Shi, Y Wang, X Yan, X Ma, A Duan, F Hassan… - Msystems, 2023 - Am Soc Microbiol
Calf diarrhea is a multifactorial disease that affects the cattle industry and accounts for more
than 50% of calf mortality. Although there is evidence of an association between altered gut …

Weaning alters intestinal gene expression involved in nutrient metabolism by shaping gut microbiota in pigs

Q Meng, Z Luo, C Cao, S Sun, Q Ma, Z Li… - Frontiers in …, 2020 - frontiersin.org
Weaning transition usually impairs intestinal architecture and functions and results in gut-
associated disorders in pigs. Understanding the changes in intestinal transcriptome and gut …

Fecal microbiota transplantation shows marked shifts in the multi-omic profiles of porcine post-weaning diarrhea

Y Su, X Li, D Li, J Sun - Frontiers in Microbiology, 2021 - frontiersin.org
Weaning is the most critical phase in pig production and is generally associated with
significant impacts on intestinal morphology, structure, physiology, and immune responses …

Structure and function of the fecal microbiota in diarrheic neonatal piglets

Q Yang, X Huang, S Zhao, W Sun, Z Yan… - Frontiers in …, 2017 - frontiersin.org
Diarrhea is a leading cause of increased mortality in neonatal and young piglets. Aberration
of the gut microbiota is one important factor in the etiology of piglet diarrhea. However …