Despite low levels of cannabinoid receptor type 2 (CB2R) expression in the central nervous
system in human and rodents, a growing body of evidence shows CB2R involvement in …

Cannabinoids are the constituents of the marijuana plant (Cannabis sativa). There are
numerous cannabinoids and other natural compounds that have been reported in the …

There is now a large body of data indicating that the cannabinoid receptor type 2 (CB2) is
linked to a variety of immune events. This functional relevance appears to be most salient in …

Based on its wide expression in immune cells, type-2 cannabinoid (CB 2) receptors were
traditionally thought to act as⿿ peripheral receptors⿿ with an almost exclusively …

Endocannabinoids are released following brain injury and may protect against excitotoxic
damage during the acute stage of injury. Brain injury also activates microglia in a secondary …

Microglia are key to maintaining the homeostasis of the brain. These immune cells of the
brain can be our biggest ally in fighting infections, but can worsen pathology or hinder …

Background: Neuroinflammation is a key feature shared by most, if not all, neuropathologies.
It involves complex biological processes that act as a protective mechanism to fight against …

Cannabinoid 1 receptors (CB1) are highly expressed on presynaptic terminals in the brain
where they are importantly involved in the control of neurotransmitter release. Alteration of …

Key points The effects of cannabinoids are primarily mediated by two types of cannabinoid
receptors, CB1 receptors in the nervous system and CB2 receptors in the immune system …

The presence of functional cannabinoid CB2 receptors in the CNS has provoked
considerable controversy over the past few years. Formerly considered as an exclusively …