Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the
most important. It is crucial to the very process that enables the chambers of the heart to …

Calcium is central in the regulation of cardiac contractility, growth and gene expression.
Variations in the amplitude, frequency and compartmentalization of calcium signals are …

Contraction of cardiac myocytes is governed by calcium-ion (Ca 2+)-induced Ca 2+ release
(CICR) from the sarcoplasmic reticulum through Ca 2+-release channels. Ca 2+ release …

Calcium (Ca2+) is a critical regulator of cardiac myocyte function. Principally, Ca2+ is the
link between the electrical signals that pervade the heart and contraction of the myocytes to …

Cardiac calcium signalling Page 1 930 Biochemical Society Transactions (2003) Volume 31,
part 5 Cardiac calcium signalling MJ Berridge1 Laboratory of Molecular Signalling, The …

Abstract Ca2+-induced Ca2+ release is a general mechanism that most cells use to amplify
Ca2+ signals,,,,. In heart cells, this mechanism is operated between voltage-gated L-type …

Sodium channels are principal molecular determinants responsible for myocardial
conduction and maintenance of the cardiac rhythm. Calcium ions (Ca2+) have a …

The simple, ionized form of the element calcium belies its value as a key carrier of
information in cells. Just over a decade ago, this messenger was first seen: Calcium …

Calcium (Ca) is a multifunctional regulator of diverse cellular functions. In cardiac muscle Ca
is a direct central mediator of electrical activation, ion channel gating, and excitation …

Ca2+ channels and calmodulin (CaM) are two prominent signalling hubs that synergistically
affect functions as diverse as cardiac excitability, synaptic plasticity and gene transcription. It …