[HTML][HTML] Ratiometric photoacoustic imaging of endoplasmic reticulum polarity in injured liver tissues of diabetic mice

H Xiao, C Wu, P Li, W Gao, W Zhang, W Zhang… - Chemical …, 2017 - pubs.rsc.org
As one of the complications of diabetes, liver injury results in significant hazards. Therefore,
accurately diagnosing diabetes-induced liver injury beforehand is crucial for the warning …

Engineering a ratiometric photoacoustic probe with a hepatocyte-specific targeting ability for liver injury imaging

XP Fan, W Yang, TB Ren, S Xu, XY Gong… - Analytical …, 2022 - ACS Publications
In situ imaging of biological indicators is imperative for pathological research by utilizing an
activatable photoacoustic (PA) probe. However, precise imaging in actual applications is …

Diagnosing drug-induced liver injury by multispectral optoacoustic tomography and fluorescence imaging using a leucine-aminopeptidase-activated probe

Y Huang, Y Qi, C Zhan, F Zeng, S Wu - Analytical chemistry, 2019 - ACS Publications
Drug-induced liver injury (DILI) is a frequent cause of hepatic dysfunction as well as the
single most frequent reason for removing approved medications from the market, and …

Rational design of dual ratiometric photoacoustic and fluorescent probe for reliable imaging and quantitative detection of endogenous CO during drug-induced liver …

L Liu, J Xu, S Zhang, H Chen, L Wang, X Shen… - Sensors and Actuators B …, 2022 - Elsevier
Carbon monoxide (CO) is an essential gaseous signaling molecule and strongly associated
with many physiological and pathological processes. The study of CO chemistry in biology …

Ratiometric Detection of H2S in Liver Injury by Activated Two-Wavelength Photoacoustic Imaging

R Wu, Z Chen, H Huo, L Chen, L Su, X Zhang… - Analytical …, 2022 - ACS Publications
Metformin is commonly used for clinical treatment of type-2 diabetes, but long-term or
overdose intake of metformin usually causes selective upregulation of H2S level in the liver …

Simultaneous fluorescence visualization of endoplasmic reticulum superoxide anion and polarity in myocardial cells and tissue

H Xiao, C Wu, P Li, B Tang - Analytical chemistry, 2018 - ACS Publications
Diabetic cardiomyopathy (DCM) is a critical complication of diabetes, the accurate
pathogenesis of which remains elusive. It is widely accepted that endoplasmic reticulum …

An activatable near-infrared molecular reporter for fluoro-photoacoustic imaging of liver fibrosis

M Miao, J Miao, Y Zhang, J Zhang, M She… - Biosensors and …, 2023 - Elsevier
Noninvasive and accurate detection of liver fibrosis is extremely significant for well-timed
intervention and treatment to prevent or reverse its progression. Fluorescence imaging …

Non-solvatochromic cell membrane-targeted NIR fluorescent probe for visualization of polarity abnormality in drug-induced liver injury mice

B Zheng, Y Tian, S Liu, J Yang, F Wu… - Analytical …, 2023 - ACS Publications
Noninvasive visualization of liver polarity by using fluorescence imaging technology is
helpful to better understand drug-induced liver injury (DILI). However, cell membrane …

An activatable probe for detecting alcoholic liver injury via multispectral optoacoustic tomography and fluorescence imaging

J Chen, Y Fang, L Sun, F Zeng, S Wu - Chemical Communications, 2020 - pubs.rsc.org
A probe has been developed for imaging alcoholic liver injury through detecting the
overexpressed cytochrome P450 reductase in hypoxia in the hepatic region. Upon response …

Rational design of a near-infrared ratiometric probe with a large stokes shift: visualization of polarity abnormalities in non-alcoholic fatty liver model mice

Y Ma, B Guo, JY Ge, L Chen, N Lv, X Wu… - Analytical …, 2022 - ACS Publications
Tracking liver polarity with noninvasive and dynamic imaging techniques is helpful to better
understand the non-alcoholic fatty liver (NAFL). Herein, a novel near-infrared (NIR) …