High sucrose consumption promotes obesity whereas its low consumption induces oxidative stress in Drosophila melanogaster

BM Rovenko, OI Kubrak, DV Gospodaryov… - Journal of insect …, 2015 - Elsevier
The effects of sucrose in varied concentrations (0.25–20%) with constant amount of yeasts in
larval diet on development and metabolic parameters of adult fruit fly Drosophila …

Dietary Sucrose Determines Stress Resistance, Oxidative Damages, and Antioxidant Defense System in Drosophila

O Strilbytska, T Strutynska, U Semaniuk… - …, 2022 - Wiley Online Library
Varied nutritional interventions affect lifespan and metabolic health. Abundant experimental
evidence indicates that the carbohydrate restriction in the diet induces changes to support …

High consumption of fructose rather than glucose promotes a diet-induced obese phenotype in Drosophila melanogaster

BM Rovenko, NV Perkhulyn, DV Gospodaryov… - … and Physiology Part A …, 2015 - Elsevier
During the last 20 years, there has been a considerable scientific debate about the possible
mechanisms of induction of metabolic disorders by reducing monosaccharides such as …

Similar effects of high-fructose and high-glucose feeding in a Drosophila model of obesity and diabetes

LP Musselman, JL Fink, TJ Baranski - PLoS One, 2019 - journals.plos.org
As in mammals, high-sucrose diets lead to obesity and insulin resistance in the model
organism Drosophila melanogaster (called Drosophila hereafter). To explore the relative …

Drosophila melanogaster larvae fed by glucose and fructose demonstrate difference in oxidative stress markers and antioxidant enzymes of adult flies

V Lushchak, BM Rovenko, DV Gospodaryov… - … and Physiology Part A …, 2011 - Elsevier
Activities of antioxidant and associated enzymes, and oxidative stress markers were
assessed in newly enclosed adult fruit flies Drosophila melanogaster developed on diets …

High amylose starch consumption induces obesity in Drosophila melanogaster and metformin partially prevents accumulation of storage lipids and shortens lifespan …

OB Abrat, JM Storey, KB Storey, VI Lushchak - … and Physiology Part A …, 2018 - Elsevier
There are very few studies that have directly analyzed the effects of dietary intake of slowly
digestible starches on metabolic parameters of animals. The present study examined the …

Dietary live yeast alters metabolic profiles, protein biosynthesis and thermal stress tolerance of Drosophila melanogaster

H Colinet, D Renault - Comparative Biochemistry and Physiology Part A …, 2014 - Elsevier
The impact of nutritional factors on insect's life-history traits such as reproduction and
lifespan has been excessively examined; however, nutritional determinant of insect's …

Dietary protein: carbohydrate balance is a critical modulator of lifespan and reproduction in Drosophila melanogaster: a test using a chemically defined diet

KP Lee - Journal of insect physiology, 2015 - Elsevier
Macronutrient balance is an important determinant of fitness in many animals, including
insects. Previous studies have shown that altering the concentrations of yeast and sugar in …

[HTML][HTML] Sugar-induced obesity and insulin resistance are uncoupled from shortened survival in Drosophila

E van Dam, LAG van Leeuwen, E Dos Santos, J James… - Cell metabolism, 2020 - cell.com
High-sugar diets cause thirst, obesity, and metabolic dysregulation, leading to diseases
including type 2 diabetes and shortened lifespan. However, the impact of obesity and water …

Drosophila melanogaster as a Model Organism for Obesity and Type-2 Diabetes Mellitus by Applying High-Sugar and High-Fat Diets

N Baenas, AE Wagner - Biomolecules, 2022 - mdpi.com
Several studies have been published introducing Drosophila melanogaster as a research
model to investigate the effects of high-calorie diets on metabolic dysfunctions. However …