High-fidelity DNA replication is critical for the faithful transmission of genetic information to
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …

Preservation of genome integrity is an essential process for cell homeostasis. During the
course of life of a single cell, the genome is constantly damaged by endogenous and …

The DNA damage response network guards the stability of the genome from a plethora of
exogenous and endogenous insults. An essential feature of the DNA damage response …

The replication stress response, which serves as an anticancer barrier, is activated not only
by DNA damage and replication obstacles but also oncogenes, thus obscuring how cancer …

DNA replication must be tightly regulated to ensure that the genome is accurately duplicated
during each cell cycle. When these regulatory mechanisms fail, replicative stress and DNA …

The human cellular genome is under constant stress from extrinsic and intrinsic factors,
which can lead to DNA damage and defective replication. In normal cells, DNA damage …

DNA damage is a constant source of stress challenging genomic integrity. To ensure faithful
duplication of our genomes, mechanisms have evolved to deal with damage encountered …

Accurate DNA replication is constantly threatened by DNA lesions arising from endogenous
and exogenous sources. Specialized DNA replication stress response pathways ensure …

DNA damage has been long recognized as causal factor for cancer development. When
erroneous DNA repair leads to mutations or chromosomal aberrations affecting oncogenes …

Oncogene activation disturbs cellular processes and accommodates a complex landscape
of changes in the genome that contribute to genomic instability, which accelerates mutation …