Distinct stages in stress granule assembly and disassembly

JR Wheeler, T Matheny, S Jain, R Abrisch, R Parker - elife, 2016 - elifesciences.org
Stress granules are non-membrane bound RNA-protein (RNP) assemblies that form when
translation initiation is limited and contain a biphasic structure with stable core structures …

[PDF][PDF] G3BP1 is a tunable switch that triggers phase separation to assemble stress granules

P Yang, C Mathieu, RM Kolaitis, P Zhang, J Messing… - Cell, 2020 - cell.com
The mechanisms underlying ribonucleoprotein (RNP) granule assembly, including the basis
for establishing and maintaining RNP granules with distinct composition, are unknown. One …

[HTML][HTML] The integral role of RNA in stress granule formation and function

D Campos-Melo, ZCE Hawley… - Frontiers in Cell and …, 2021 - frontiersin.org
Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …

Principles and properties of stress granules

DSW Protter, R Parker - Trends in cell biology, 2016 - cell.com
Stress granules are assemblies of untranslating messenger ribonucleoproteins (mRNPs)
that form from mRNAs stalled in translation initiation. Stress granules form through …

[PDF][PDF] RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation

J Guillén-Boixet, A Kopach, AS Holehouse, S Wittmann… - Cell, 2020 - cell.com
Stressed cells shut down translation, release mRNA molecules from polysomes, and form
stress granules (SGs) via a network of interactions that involve G3BP. Here we focus on the …

RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome

B Van Treeck, DSW Protter… - Proceedings of the …, 2018 - National Acad Sciences
Stress granules are higher order assemblies of nontranslating mRNAs and proteins that
form when translation initiation is inhibited. Stress granules are thought to form by protein …

[HTML][HTML] Molecular mechanisms of stress granule assembly and disassembly

S Hofmann, N Kedersha, P Anderson… - Biochimica et Biophysica …, 2021 - Elsevier
Stress granules (SGs) are membrane-less ribonucleoprotein (RNP)-based cellular
compartments that form in the cytoplasm of a cell upon exposure to various environmental …

Isolation of yeast and mammalian stress granule cores

JR Wheeler, S Jain, A Khong, R Parker - Methods, 2017 - Elsevier
Stress granules are dynamic, conserved RNA-protein (RNP) assemblies that form when
translation is limiting; and are related to pathological aggregates in degenerative disease …

Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules

S Kroschwald, S Maharana, D Mateju, L Malinovska… - elife, 2015 - elifesciences.org
RNA-protein (RNP) granules have been proposed to assemble by forming solid RNA/protein
aggregates or through phase separation into a liquid RNA/protein phase. Which model …

mRNP architecture in translating and stress conditions reveals an ordered pathway of mRNP compaction

A Khong, R Parker - Journal of Cell Biology, 2018 - rupress.org
Stress granules (SGs) are transient membraneless organelles of nontranslating mRNA–
protein complexes (mRNPs) that form during stress. In this study, we used multiple single …