Human telomerase assembly is a highly dynamic process. Using biochemical approaches,
we found that LARP3 and LARP7/MePCE are involved in the early stage and that their …

Human telomerase assembly is a highly dynamic process. Using biochemical approaches,
we find that LARP3 and LARP7/MePCE are involved in the early stage of human telomerase …

Understanding the intricacies of telomerase regulation is crucial due to the potential health
benefits of modifying its activity. Telomerase is composed of an RNA component and …

Telomere maintenance protects the cell against genome instability and senescence.
Accelerated telomere attrition is a characteristic of premature aging syndromes including …

RTEL1 is an ATP-dependent DNA helicase that translocates on the single-stranded DNA
(ssDNA) from 5′ to 3′ direction. It is an iron-sulfur (Fe-S) cluster and DEAH motif …

Telomeres cap the ends of eukaryotic chromosomes and distinguish them from broken DNA
ends to suppress DNA damage response, cell cycle arrest and genomic instability …

Maintenance of telomeres is essential for genome integrity and replicative capacity in
eukaryotic cells. Telomerase, the ribonucleoprotein complex that catalyses telomere …

Human telomerase RNA (hTR) is transcribed as a precursor that is then posttranscriptionally
modified and processed. A fraction of the transcripts is oligoadenylated by TRAMP and …

Telomere maintenance in eukaryotes is linked to cellular proliferation capacity. The
telomerase holoenzyme, which maintains telomere length, is a central actor in this process …

Telomerase RNA has been uncovered as a component of the telomerase enzyme, which
acts as a reverse transcriptase and maintains the length of telomeres in proliferated …