Neural stem cell therapy for subacute and chronic ischemic stroke

AC Boese, QSE Le, D Pham, MH Hamblin… - Stem cell research & …, 2018 - Springer
Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire
of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a …

Neural stem cells for early ischemic stroke

MH Hamblin, JP Lee - International journal of molecular sciences, 2021 - mdpi.com
Clinical treatments for ischemic stroke are limited. Neural stem cell (NSC) transplantation
can be a promising therapy. Clinically, ischemia and subsequent reperfusion lead to …

Neural stem cells therapy for ischemic stroke: progress and challenges

T Zhao, T Zhu, L Xie, Y Li, R Xie, F Xu, H Tang… - Translational stroke …, 2022 - Springer
Ischemic stroke, with its high morbidity and mortality, is the most common cerebrovascular
accident and results in severe neurological deficits. Despite advances in medical and …

Neural stem cell transplantation in ischemic stroke: a role for preconditioning and cellular engineering

JD Bernstock, L Peruzzotti-Jametti… - Journal of Cerebral …, 2017 - journals.sagepub.com
Ischemic stroke continues to be a leading cause of morbidity and mortality throughout the
world. To protect and/or repair the ischemic brain, a multitiered approach may be centered …

Opportunities and challenges: stem cell‐based therapy for the treatment of ischemic stroke

YH Tang, YY Ma, ZJ Zhang, YT Wang… - CNS neuroscience & …, 2015 - Wiley Online Library
Stem cell‐based therapy for ischemic stroke has been widely explored in animal models
and provides strong evidence of benefits. In this review, we summarize the types of stem …

Efficacy of stem cell-based therapies for stroke

MR Chrostek, EG Fellows, AT Crane, AW Grande… - Brain research, 2019 - Elsevier
Stroke remains a prevalent disease with limited treatment options. Available treatments offer
little in the way of enhancing neurogenesis and recovery. Because of the limitations of …

Neural stem cell therapy for stroke: A multimechanistic approach to restoring neurological function

EW Baker, HA Kinder, FD West - Brain and behavior, 2019 - Wiley Online Library
Abstract Introduction Neural stem cells (NSCs) have demonstrated multimodal therapeutic
function for stroke, which is the leading cause of long‐term disability and the second leading …

Potential of stem/progenitor cells in treating stroke: the missing steps in translating cell therapy from laboratory to clinic

CV Borlongan, M Chopp, GK Steinberg… - Regenerative …, 2008 - Taylor & Francis
Accumulating laboratory evidence demonstrates the potential of transplanting
stem/progenitor cells for treating CNS disorders. The realization of neuroprotection or …

Cell based therapies for ischemic stroke: from basic science to bedside

X Liu, R Ye, T Yan, SP Yu, L Wei, G Xu, X Fan… - Progress in …, 2014 - Elsevier
Cell therapy is emerging as a viable therapy to restore neurological function after stroke.
Many types of stem/progenitor cells from different sources have been explored for their …

Stem cell research in stroke: how far from the clinic?

O Lindvall, Z Kokaia - Stroke, 2011 - Am Heart Assoc
Stem cell-based approaches hold much promise as potential novel treatments to restore
function after stroke. Studies in animal models have shown that stem cell transplantation can …