Nuclear factor-κB (NF-κB) has been widely implicated in the development and progression
of cancer. In colorectal cancer (CRC), NF-κB has a key role in cancer-related processes …

Importance of the field: Colorectal cancer (CRC) is the second leading cause of cancer
death. Progress has been made in the development of chemotherapy for advanced CRC …

Colorectal cancer (CRC) is the second leading cause of cancer death. Progress has been
made in the development of chemotherapy for advanced CRC. Targeted therapies against …

There is growing evidence for a connection between inflammation and tumor development,
and the nuclear factor kappa B (NF-κB), a proinflammatory transcription factor, is …

Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide,
responsible for more than half a million deaths annually. CRC is a multistep process that …

Colitis-associated cancer is the subtype of colorectal cancer that is associated with
inflammatory bowel diseases including ulcerative colitis and Crohn's disease. Colorectal …

Purpose: Nuclear factor κB (NF-κB) is an important transcription factor in various biological
processes. Constitutive NF-κB activation has been noted in many tumors, including …

The NF-κB signaling pathway is a key regulator of CRC cell proliferation, apoptosis,
angiogenesis, inflammation, metastasis, and drug resistance. Over-activation of the NF-κB …

Colorectal cancer (CRC) is among the most common types of cancer attributed to genetic
alterations. Its manifestation implicates NF-κB and AP-1 signaling pathways by virtue of their …

Importance of the field: Nuclear factor kappa B (NF-κB) is activated by a variety of cancer-
promoting agents. The reciprocal activation between NF-κB and inflammatory cytokines …