Early life exposure to stress can lead to physiological and behavioural adaptations in
offspring. Adaptive changes do not always benefit the organism, as it may result in adult …

Parental exposure to stress or glucocorticoids either before or during pregnancy can have
profound influences on neurodevelopment, neuroendocrine function and behaviours in …

Since their first use in 1972 by Liggins and Howie, prenatal exposure to synthetic
glucocorticoids (GCs) is commonplace in antenatal medicine to impede the preterm birth …

Early life environmental events have persisting effects on tissue structure and function, a
phenomenon called 'developmental programming'. Exposure to stress and its glucocorticoid …

Numerous clinical studies associate an adverse prenatal environment with the development
of cardio-metabolic disorders and neuroendocrine dysfunction, as well as an increased risk …

The embryo and fetus are highly responsive to the gestational environment. Glucocorticoids
(GC) represent an important class of developmental cues and are crucial for normal brain …

The early nurturing environment has persistent influences on developmental programming
of inter-individual differences in metabolic and endocrine function that contribute to …

Fetal exposure to high levels of glucocorticoids programs long-term changes in the
physiologic stress response and behaviours. However, it is not known whether effects …

Antenatal glucocorticoid (GC) exposure is a potent modifier of the hypothalamic-pituitary-
adrenal (HPA) axis. We previously observed increased cortisol secretion in response to …

Human epidemiological and animal studies show that many chronic adult conditions have
their antecedents in compromised fetal and early postnatal development. Mother–infant …