Role of cytokines in the pathogenesis of inflammatory bowel disease

KA Papadakis, SR Targan - Annual review of medicine, 2000 - annualreviews.org
Recent advances in the drug treatment of inflammatory bowel disease (IBD) have paralleled
our understanding of the pathophysiology of ulcerative colitis and Crohn's disease. Several …

Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases

W Strober, IJ Fuss - Gastroenterology, 2011 - Elsevier
The cytokine responses characterizing the inflammatory bowel diseases are the key
pathophysiologic elements that govern the initiation, evolution, and, ultimately, the resolution …

[HTML][HTML] New strategies for treatment of inflammatory bowel disease

OH Nielsen - Frontiers in medicine, 2014 - frontiersin.org
The etiology of inflammatory bowel disease (IBD), of which ulcerative colitis (UC) and
Crohn's disease (CD) are the two most prevailing entities, is unknown. However, IBD is …

Advances in understanding the role of cytokines in inflammatory bowel disease

G Bevivino, G Monteleone - Expert review of gastroenterology & …, 2018 - Taylor & Francis
Introduction: Cytokines represent the key pathophysiologic elements that govern the
initiation, progression, and, in some circumstances, the resolution of the inflammation …

Cytokine therapy for Crohn's disease: advances in translational research

TT Pizarro, F Cominelli - Annu. Rev. Med., 2007 - annualreviews.org
Crohn's disease (CD) and ulcerative colitis (UC), the two idiopathic inflammatory bowel
diseases (IBDs), affect almost two million individuals in North America and several million …

[HTML][HTML] Role of cytokines in inflammatory bowel disease

F Sanchez-Muñoz, A Dominguez-Lopez… - World journal of …, 2008 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative
colitis (UC), represents a group of chronic disorders characterized by inflammation of the …

New cytokine therapeutics for inflammatory bowel disease

PCF Stokkers, DW Hommes - Cytokine, 2004 - Elsevier
Conventional therapy for inflammatory bowel diseases rely on corticosteroids and 5-
aminosalicylates combined with immunosuppressive agents for maintenance. These drugs …

Anti-and proinflammatory cytokines in the pathogenesis of tissue damage in Crohn's disease

DW Hommes, SJH van Deventer - Current Opinion in Clinical …, 2000 - journals.lww.com
Crohn's disease is a chronic inflammatory bowel disease of unknown origin. The
understanding of the pathogenesis of inflammatory bowel diseases has been greatly …

Systemic molecular mediators of inflammation differentiate between Crohn's disease and ulcerative colitis, implicating threshold levels of IL-10 and relative ratios of …

MG Kiernan, JC Coffey, SM Sahebally… - Journal of Crohn's …, 2020 - academic.oup.com
Abstract Background and Aims Faecal diversion is associated with improvements in Crohn's
disease but not ulcerative colitis, indicating that differing mechanisms mediate the diseases …

[HTML][HTML] Interleukin-12 and Th1 immune response in Crohn's disease: Pathogenetic relevance and therapeutic inplication

I Peluso, F Pallone, G Monteleone - World journal of …, 2006 - ncbi.nlm.nih.gov
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory disorders of the
gastrointestinal tract that share clinical and pathological characteristics. The most accredited …