SUMO: from bench to bedside

HM Chang, ETH Yeh - Physiological Reviews, 2020 - journals.physiology.org
Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates
multiple biological processes, including cell division, DNA replication/repair, signal …

Mapping the SUMO ylated landscape

K Eifler, ACO Vertegaal - The FEBS journal, 2015 - Wiley Online Library
SUMO ylation is a post‐translational modification that regulates a multitude of cellular
processes, including replication, cell‐cycle progression, protein transport and the DNA …

[HTML][HTML] Specification of SUMO1-and SUMO2-interacting motifs

CM Hecker, M Rabiller, K Haglund, P Bayer… - Journal of Biological …, 2006 - ASBMB
SUMO proteins are ubiquitin-related modifiers implicated in the regulation of gene
transcription, cell cycle, DNA repair, and protein localization. The molecular mechanisms by …

SUMO proteases: from cellular functions to disease

LA Claessens, ACO Vertegaal - Trends in Cell Biology, 2024 - cell.com
Posttranslational modification by small ubiquitin-like modifiers (SUMOs) is critical in
regulating diverse cellular processes including gene expression, cell cycle progression …

SUMO-specific proteases and isopeptidases of the SENP family at a glance

K Kunz, T Piller, S Müller - Journal of cell science, 2018 - journals.biologists.com
The ubiquitin-related SUMO system controls many cellular signaling networks. In
mammalian cells, three SUMO forms (SUMO1, SUMO2 and SUMO3) act as covalent …

Ubiquitin-dependent and independent roles of SUMO in proteostasis

F Liebelt, ACO Vertegaal - American Journal of Physiology …, 2016 - journals.physiology.org
Cellular proteomes are continuously undergoing alterations as a result of new production of
proteins, protein folding, and degradation of proteins. The proper equilibrium of these …

[HTML][HTML] Emerging roles of desumoylating enzymes

JH Kim, SH Baek - Biochimica et Biophysica ACTA (BBA)-Molecular Basis …, 2009 - Elsevier
Posttranslational modification by small ubiquitin-like modifier (SUMO) controls diverse
cellular processes including transcriptional regulation, nuclear transport, cell-cycle …

SUMO and ubiquitin paths converge

A Denuc, G Marfany - Biochemical Society Transactions, 2010 - portlandpress.com
One of the more rapidly expanding fields in cell signalling nowadays is the characterization
of proteins conjugated to Ub (ubiquitin) or Ub-like peptides, such as SUMO (small Ub …

Detecting endogenous SUMO targets in mammalian cells and tissues

J Becker, SV Barysch, S Karaca, C Dittner… - Nature structural & …, 2013 - nature.com
SUMOylation is an essential modification that regulates hundreds of proteins in eukaryotic
cells. Owing to its dynamic nature and low steady-state levels, endogenous SUMOylation is …

[HTML][HTML] SUMOylation and De-SUMOylation: wrestling with life's processes

ETH Yeh - Journal of Biological Chemistry, 2009 - ASBMB
The small ubiquitin-like modifier (SUMO) is a ubiquitin-like protein that covalently modifies a
large number of cellular proteins. SUMO modification has emerged as an important …