The current anti-TB treatment consists of a prolonged multi-drug therapy. Interventional
strategies are required to reduce the chemotherapeutic load. In this regard, we have …

Background: Tuberculosis is one of the leading causes of mortality worldwide. Resistance
against the frontline anti-tubercular drugs has worsened the already alarming situation …

The mechanism of action of artemisinin antimalarials may be ascribed to C-centered
radicals that alkylate biomolecules or to the peroxide moiety, which inhibits a specific, as yet …

Tuberculosis is a major infectious disease that globally causes the highest human mortality.
From this aspect, this study was carried out to evaluate novel pharmacological …

Artermisinin and its derivatives are now the mainstays of antimalarial treatment; however,
their mechanism of action is only poorly understood. We report on the synthesis of a novel …

Azithromycin when used in combination with faster-acting antimalarials has proven
efficacious in treating Plasmodium falciparum malaria in phase 2 clinical trials. The aim of …

As artemisinin combination therapies (ACTs) are compromised by resistance, we are
evaluating triple combination therapies (TACTs) comprising an amino-artemisinin, a redox …

During the past decade, artemisinin as an antimalarial has been in the spotlight, in part due
to the Nobel Prize in Physiology or Medicine awarded to Tu Youyou. While many studies …

In a recent article in the Journal of Antimicrobial Chemotherapy, Saralamba and colleagues
1 present a pharmacological model of artemisinin treatment in which they argue that …

A recent Letter to the Editor (RK Haynes, D. Monti, D. Taramelli, N. Basilico, S. Parapini, and
P. Olliaro, Letter, Antimicrob. Agents Chemother. 47: 1175, 2003) presented cogent …